Evidence map›Paper›PMID 40917795›Full record

ArticleImmune network2025

Pediatric Atopic Dermatitis Exhibits Distinctive Patterns in JAK/STAT Pathway Activation and CD6-ALCAM Signaling.

Soyoung Jeong, Sanghee Shin, Hyun Seung Choi, So-Jung Choi, Sehun Jang, Jeongmin Song, Ji Su Lee, Dong Hun Lee, Hyun Je Kim, Jihyun Kim and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immune network, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Soyoung JeongDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.ORCID https://orcid.org/0000-0003-0911-0567
Sanghee ShinDepartment of Pediatrics, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Korea.ORCID https://orcid.org/0000-0002-7923-8657
Hyun Seung ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-6217-4714
So-Jung ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.ORCID https://orcid.org/0009-0005-9544-5233
Sehun JangDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam 23488, Korea.ORCID https://orcid.org/0000-0002-2841-0648
Jeongmin SongDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.ORCID https://orcid.org/0009-0005-9216-3724
Ji Su LeeDepartment of Dermatology, Seoul National University Hospital, Seoul 03080, Korea.ORCID https://orcid.org/0000-0003-0207-2107
Dong Hun LeeDepartment of Dermatology, Seoul National University Hospital, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-2925-3074
Hyun Je KimDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Korea.ORCID https://orcid.org/0000-0003-4467-0949
Jihyun KimDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.ORCID https://orcid.org/0000-0001-8493-2881
Kangmo AhnDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.ORCID https://orcid.org/0000-0001-7751-9829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric atopic dermatitis (AD) shows distinct clinical characteristics compared to adult AD, suggesting unique inflammatory profiles that may influence disease prognosis and treatment response. We aimed to identify unique immune signatures of pediatric AD and investigate the differences between pediatric and adult AD patients. Nine pediatric (6-16 years) and 12 adult (20-60 years) were enrolled. PBMCs were collected from AD patients and age- and sex-matched healthy controls (HCs). Transcriptomic profiles were analyzed using single-cell RNA sequencing, and the immune phenotypes of adult and pediatric AD were compared. Th2 gene expression was elevated in both adult and pediatric AD, while Th1, Th17, and Th22 gene expression was downregulated in pediatric AD but not in adults. Genes involved in JAK/STAT signaling pathway, which were upregulated in adult AD, were not significantly increased in pediatric AD. The CD6-activated leukocyte cell adhesion molecule (ALCAM) pathway was upregulated in pediatric AD compared to pediatric HCs, but not in adult AD. Pediatric AD reveals distinct immune signatures, including a lack of JAK/STAT pathway upregulation observed in adult AD and a unique activation of the CD6-ALCAM pathway. These findings highlight the importance of age-specific treatment strategies in AD patients.

Indexed as

ALCAMAtopic dermatitisBiologicsChildJAK kinasesSingle-cell RNA-seq

Identifiers

PMID40917795
PMCPMC12411110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.