ArticleGastro hep advances2025
Extraintestinal Symptoms of Pain Are Common in Patients With Eosinophilic Gastrointestinal Diseases.
Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background and Aims: Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extragastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient-reported joint or leg pain and headache for EoE and non-EoE EGIDs individuals. Methods: Adult subjects and caregivers of children were recruited via the EGID Partners network and completed the Short-Form McGill Pain Questionnaire and Migraine Disability Assessment Test. T-tests were used to evaluate differences in extraintestinal pain symptomology by EGID type. Results: We analyzed 95 subjects with EoE only and 24 subjects with non-EoE only EGIDs. Both EoE and non-EoE EGID subjects described frequent leg pain (50% and and 78%, respectively). While no significant difference was observed in number of days of leg pain, pain severity was higher for non-EoE EGID subjects ( Conclusion: Patients with EGIDs may experience extraintestinal symptoms of pain. These symptoms may be more prominent in patients with non-EoE only EGIDs. Understanding of the underlying factors contributing to these symptoms is needed to guide mitigating approaches for these symptoms.
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