ArticleFrontiers in cell and developmental biology2025
Refractive error after phacoemulsification combined with intraocular lens implantation in primary angle-closure glaucoma: a multifactorial analysis of biometric parameters and surgical strategies.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aims to explore the factors influencing refractive error following Phacoemulsification combined with intraocular lens implantation (PE + IOL) in patients with primary angle-closure glaucoma (PACG), providing a theoretical basis for preoperative consultation and IOL power selection in clinical practice. Methods: A retrospective analysis was conducted on 404 PACG patients from Shenzhen Eye Hospital between 2019 and 2024. Preoperative ocular biometric parameters and combined surgical approaches were evaluated using Spearman correlation, multinomial logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: Axial length (AL), lens thickness (LT), and white-to-white distance (WTW) were key predictive factors for prediction error and postoperative refractive outcomes. AL > 22.56 mm (AUC = 0.692) and LT > 5.055 mm (AUC = 0.633) increased the risk of myopic shift (MS), while AL < 22.25 mm (AUC = 0.604) and WTW <11.55 mm (OR = 2.209, Conclusion: The unique anatomical characteristics of PACG patients are key contributors to postoperative refractive instability. Preoperative assessment for PE + IOL surgery should comprehensively evaluate AL, LT, WTW, and AL/CR ratio. When combined with other surgical approaches to control intraocular pressure, IOL power should be adjusted according to these thresholds to ensure postoperative refractive stability.
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