ArticleInternational journal of women's health2025
The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Health literacy and urban-rural disparities: a cross-sectional study of access, adherence, and quality of life across the neurological spectrum.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Female reproductive disorders (FRDs) are common diseases among women of childbearing age, affecting their reproductive health. Age at first sexual intercourse (AFS) is potentially linked to FRDs, and this study aims to investigate these associations and underlying mechanisms, to offer new insights and guidance for sex education in adolescent women and reproductive health management. Methods: Mendelian randomization (MR) analysis was performed using summary data from genome-wide association studies (GWASs). The AFS summary data were sourced from 397,338 European participants, and the outcome data were obtained from the FinnGen consortium. Additionally, multivariate MR (MVMR) and mediation analyses were also adopted to explore more detailed association. The MR results were rigorously validated, with the inverse variance weighted (IVW) method employed as the primary approach to assess causal relationships. Results: There is a significant causal relationship between AFS and ovarian dysfunction (OD), polycystic ovarian syndrome (PCOS), and spontaneous abortion (0.45 [0.25-0.81], p=0.008; 0.35 [0.17-0.74], p=0.006; 0.76 [0.63-0.92], p=0.006). Among them, the genetic association between AFS and spontaneous abortion remained significant even after adjusting for more confounding variables (0.73 [0.55-0.95], p=0.020; 0.76 [0.61-0.95], p=0.015), and Body mass index (BMI) may be an important mediating factor in the association between AFS and PCOS (38.41%, p=7.17e-6) or OD (35.64%, p= 1.51e-6). Conclusion: Our research suggested that early AFS is closely associated with a higher risk of reproductive disorders, and timely interventions targeting BMI may partially alleviate the adverse effects of early sexual activity on reproductive health. The analysis based on genetic data emphasizes the importance of early sex education for adolescents, while weight management can to some extent avoid the occurrence of reproductive disorders during childbearing age, which also provide scientific basis for understanding the pathogenesis of FRDs and formulating appropriate reproductive health education strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.