Evidence map›Paper›PMID 40917689›Full record

ArticleMolecular therapy. Methods & clinical development2025

Wild-type and engineered adeno-associated viral vectors produce comparable opsin expression and light-evoked responses in rat skeletal muscle.

Fiona L Knapman, E Myfanwy Cohen, Tom Kulaga, Nigel H Lovell, Leszek Lisowski, Peter G R Burke, Lynne E Bilston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fiona L KnapmanNeuroscience Research Australia, Sydney, NSW 2031, Australia.
E Myfanwy CohenNeuroscience Research Australia, Sydney, NSW 2031, Australia.
Tom KulagaGraduate School of Biomedical Engineering, UNSW, Sydney, NSW 2033, Australia.
Nigel H LovellGraduate School of Biomedical Engineering, UNSW, Sydney, NSW 2033, Australia.
Leszek LisowskiChildren's Medical Research Institute, Sydney, NSW 2145, Australia.
Peter G R BurkeNeuroscience Research Australia, Sydney, NSW 2031, Australia.
Lynne E BilstonNeuroscience Research Australia, Sydney, NSW 2031, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optogenetics offers a minimally invasive, low-fatigue, and temporally precise alternative to electrical stimulation for skeletal muscle control. After opsin expression in muscle cells, contraction can be stimulated with light. Obstructive sleep apnea, characterized by repeated airway collapse during sleep, suits this approach, as upper airway muscles are readily accessible via the oral cavity, and require stimulation synchronized to respiration. This study compared wild-type (adeno-associated virus 9 [AAV9]) and engineered (AAVMYO) viral vectors for the delivery of identical muscle-specific optogenetic constructs in rats. Three weeks after intramuscular injections, both vectors produced comparable opsin expression in the tongue (

Indexed as

AAVAAV9AAVMYOmuscle stimulationmusculoskeletaloptogeneticsskeletal muscle

Identifiers

PMID40917689
PMCPMC12409377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.