ArticleFrontiers in neurology
Percutaneous CT-guided or endoscopic spinal biopsy with accurate pathogen detection for spinal infection.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Diagnostic value of quantitative SPECT/CT integrated parameters for differentiating spinal tuberculosis from spinal metastases.Frontiers in oncology · 2026Article
- Integrating metagenomic next-generation sequencing into a multimodal diagnostic framework for spinal infection: enhancing etiological identification and clinical prediction.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Aims: In this study, we aimed to analyze the pathogen detection results in spinal infections using percutaneous CT-guided biopsy or transforaminal endoscopic spinal biopsy. Methods: This is a retrospective observational study of patients who underwent biopsy for spinal infection at Shanghai Sixth People's Hospital between December 2020 and June 2024. Data on demographics, clinical presentations, radiological findings, and histopathology were collected from medical records. Pathogen detection results from different sampling methods were evaluated. Results: A total of 131 cases of spinal infection were included in the study. The average age of the patients was 59.1 ± 13.8 years. The median time from symptom onset to diagnosis was 2 months [inter-quartile range (IQR): 1 to 4.5 months]. Clinical manifestations included pain (100%) and fever (15.27%), with the lumbar vertebra being the most commonly affected site (110/168, 65.48%). Elevated ESR, CRP, and IL-6 levels were observed in most cases. MR showed high sensitivity (90.90%) but low specificity (2.04%). Pathogen detection was performed using next-generation sequencing (mNGS) and/or microbial culture. Of the 131 patients, 66 underwent percutaneous CT-guided biopsy, and 65 underwent transforaminal endoscopic spinal biopsy. All samples were tested using mNGS, while microbial culture was performed only on abscess samples from CT-guided biopsy cases. The most commonly identified pathogens were Conclusion: Accurate pathogen diagnosis is crucial for the diagnosis and treatment of spinal infections. The microbiological detection rates of samples obtained via percutaneous CT-guided are similar to those obtained through transforaminal endoscopic spinal biopsy.
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