SynthesisFrontiers in neurology
Effect of dexmedetomidine on postoperative cognitive function in patients with gastrointestinal cancer: a meta-analysis of randomized controlled trials.
Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of dexmedetomidine on perioperative neurocognitive disorders in elderly patients undergoing non-cardiac surgery: a scoping review.Frontiers in neuroscience · 2026Pooled it
- Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This meta-analysis was conducted to systematically evaluate the effects of dexmedetomidine (DEX) on mini-mental state examination (MMSE) scores and the incidence of postoperative cognitive dysfunction (POCD) in patients with gastrointestinal cancers (GICs) undergoing radical surgery (RS), by aggregating data from randomized controlled trials (RCTs). Methods: A comprehensive literature review was undertaken that encompassed seven databases from their inception until March 4, 2024. The quality of the studies was assessed using the Cochrane Collaboration tool to evaluate risk. Based on the heterogeneity determined through Cochran's Q and I Results: A total of 12 studies involving 881 patients with GIC (440 patients treated with DEX and 441 patients receiving saline) were included in this meta-analysis. The overall quality of the included studies was deemed moderate. The application of a random-effect model indicated that DEX significantly elevated MMSE scores on postoperative days 1, 2, 3, and 7, albeit with considerable heterogeneity. Conversely, the fixed-effect model demonstrated a protective effect of DEX on the incidence of POCD. Nonetheless, subgroup analyses stratified by cancer type and surgical method did not identify the sources of heterogeneity. The Egger test revealed no evidence of publication bias across the included studies ( Discussion: The findings suggest that DEX exerts a protective effect on cognitive function in patients with GICs undergoing RS. Nevertheless, high-quality, large-scale RCTs are necessary to furnish more definitive evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.