ArticleFrontiers in neurology
Predictive immunonutritional biomarkers for the severity and recovery of sudden sensorineural hearing loss: a prospective clinical study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Serum ENA-78, CXCL1, and caspase-3 are associated with disease severity and early hearing recovery in idiopathic sudden sensorineural hearing loss.Frontiers in neuroscience · 2026Article
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4 authors.
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Abstract
Background: Systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) are known to predict the severity and prognosis of various diseases. However, their role in sudden sensorineural hearing loss (SSNHL) is unclear. Methods: This study collected 100 patients with SSNHL and 100 healthy volunteers. According to the severity, type, prognosis and SII and PNI levels of SSNHL, we used the Spearman linear correlation method to conduct correlation analysis. At the same time, we constructed logistic regression analysis to explore the predictive value of PNI and SII on the prognosis of SSNHL patients, and used ROC curves to verify the prognostic model. Cohen's d values were calculated for select significantly different parameters to assess effect sizes. Results: Compared with control group, PNI levels were significantly lowered in SSNHL patients, while SII levels were significantly higher. And a significant correlation was observed between the two variables ( Conclusion: In patients with SSNHL, PNI levels were significantly lowered, while SII levels were significantly higher. Furthermore, a negative correlation was observed between these two indicators. A negative correlation between PNI and SSNHL severity and a positive correlation between SII and severity were observed. These findings suggest that PNI and SII could serve as potential biomarkers for predicting SSNHL prognosis.
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