Evidence map›Paper›PMID 40917567›Full record

ArticleSleep advances : a journal of the Sleep Research Society2025

Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations.

Francisco Romo-Nava, Helen J Burgess, Thomas J Blom, Georgi Georgiev, Jakyb Stoddard, Elly McMillan, Nicole N Mori, Christina Charnas, Anna I Guerdjikova, Robert K McNamara and 4 more

Abstract read
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francisco Romo-NavaLindner Center of HOPE Research Institute, Mason, OH, United States.ORCID https://orcid.org/0000-0002-5894-3701
Helen J BurgessSleep and Circadian Research Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States.ORCID https://orcid.org/0000-0003-3816-8194
Thomas J BlomLindner Center of HOPE Research Institute, Mason, OH, United States.
Georgi GeorgievLindner Center of HOPE Research Institute, Mason, OH, United States.
Jakyb StoddardLindner Center of HOPE Research Institute, Mason, OH, United States.
Elly McMillanDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Nicole N MoriLindner Center of HOPE Research Institute, Mason, OH, United States.
Christina CharnasLindner Center of HOPE Research Institute, Mason, OH, United States.
Anna I GuerdjikovaLindner Center of HOPE Research Institute, Mason, OH, United States.
Robert K McNamaraDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Jeffrey A WelgeDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Carlos M GriloDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States.
Frank A J L ScheerDivision of Sleep Medicine, Harvard Medical School, Boston, MA, United States.ORCID https://orcid.org/0000-0002-2014-7582
Susan L McElroyLindner Center of HOPE Research Institute, Mason, OH, United States.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Treatment of Obesity and Binge Eating: Behavioral weight Loss versus Stepped CareR01DK049587 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2002 to 2020
$8.5M
Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A, TAVAKKOLI, ALI · 2017 to 2023
$4.2M
Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2021 to 2025
$3.9M
Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating DisorderR01DK112771 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M, MCKEE, SHERRY ANN · 2017 to 2021
$3.6M
Cognitive-Behavioral and Pharmacologic Treatment of Binge Eating DisorderR01DK114075 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2018 to 2022
$3.6M
Neurocognitive fMRI Mechanisms of CBT and Lisdexamfetamine Outcomes in Obesity and BEDR01DK121551 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M, POTENZA, MARC N · 2019 to 2023
$1.8M
Modulating spinal interoceptive pathways to evaluate their role and therapeutic potential in MDD symptomatic domainsR61MH133770 · NIMH · UNIVERSITY OF CINCINNATI · PI ROMO-NAVA, FRANCISCO · 2024 to 2025
$1.6M
The role of the circadian system in binge eating disorderK23MH120503 · NIMH · UNIVERSITY OF CINCINNATI · PI ROMO-NAVA, FRANCISCO · 2020 to 2023
$803k
NCATS NIH HHS UL1 TR001425NHLBI NIH HHS R01 HL140574NHLBI NIH HHS R01 HL153969NIDDK NIH HHS R01 DK049587NIDDK NIH HHS R01 DK112771NIDDK NIH HHS R01 DK114075NIDDK NIH HHS R01 DK121551NIMH NIH HHS K23 MH120503NIMH NIH HHS R61 MH133770
6 · The paper itself

Abstract

Study Objectives: Dim light melatonin onset (DLMO) is the best-established marker of central circadian phase and may contribute to unraveling the role of the circadian system in obesity. This study evaluated DLMO among individuals with obesity using a home-based assessment and explored its clinical correlates and procedural variations. Method: Fifty-eight women (mean [SD] age 40.9 [7.8] years) and body mass index (41.4 [6.6] kg/m Results: DLMO was detected in 98.2% and 89.6% of participants using an individualized or a standardized threshold, respectively. DLMO correlated with SOT but not with body mass index, cardiometabolic parameters, sleep quality, or diurnal preference. A later SOT and a larger phase angle of entrainment (DLMO-SOT) correlated with younger age and with eveningness. Most procedural alternatives showed good agreement with the original methods. Conclusions: Home-based assessment yielded a high rate of detectable DLMO in women with obesity. Diurnal preference was not correlated with central circadian phase, suggesting that other factors (e.g. behavioral, sociodemographic) may be relevant in chronotype assessment in this population. We offer implications for future research including procedural variations to consider.

Indexed as

body compositionbody mass indexchronotypecircadian phasedim light melatonin onsetdiurnal preferencehome-basedobesityphase anglesleep onset

Identifiers

PMID40917567
PMCPMC12413864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.