ArticleJournal of diabetes and metabolic disorders2025
NICTH with secondary acromegaloid changes and severe hypoglycemia due to potentially insulin-like growth factor-2 mediated effects.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome resulting from excessive secretion of pro-insulin-like growth factor 2 (proIGF-2). This leads to hypoinsulinemic hypoglycemia and, in some cases, acromegaly. We report the case of a 52-year-old woman with NICTH syndrome who had decreased levels of insulin-like growth factor 1 (IGF1), insulin, C-peptide, and growth hormone (GH). The patient experienced severe hypoglycemia, with blood glucose levels dropping to 42 mg/dL (normal reference range; 70-100 mg/dL and SI unit; 2.33 mmol/L), resulting in tachycardia, palpitations, and confusion. Additionally, the patient exhibited acromegaloid features, such as a coarse facial appearance and hyperpigmentation. The patient presented with shortness of breath and chest pain. A mass was found in her left lung, which was successfully removed through thoracotomy surgery, resolving her hypoglycemic symptoms.
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