Muscle-driven spinal cord histological and transcriptomic alterations in a myotonic dystrophy mouse model: insights into neuropathy.

Guanzhong Shi, Yining Luan, Yuzhen Ouyang, Kangzhi Chen, Kaiyue Zhang, Zeyi Wen, Huan Yang, Kun Huang

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Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

8 authors.

Guanzhong ShiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID https://orcid.org/0000-0003-0942-8778

Yining LuanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Yuzhen OuyangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Kangzhi ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Kaiyue ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Zeyi WenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Huan YangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Kun HuangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder characterized by muscle weakness, atrophy and myotonia, with multi-system involvement. Recent studies have highlighted the pathological heterogeneity within the CNS of DM1 patients, particularly significant changes in spinal transcriptome expression and alternative splicing. In this study, we conducted a comprehensive transcriptome analysis of the spinal cord in the muscle-specific DM1 mouse model and their wild-type controls across different life stages: young, adult and old age. Our results revealed an age-dependent increase in differential gene expression between DM1 and wild-type mice with a predominance of downregulated genes. Notably, five genes (

Indexed as

alternative splicingmicrogliamyotonic dystrophyRNA sequencingspinal cord

Identifiers

PMID40917546

DOI10.1093/braincomms/fcaf313

PMCPMC12409276

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