ArticleMaterials today. Bio2025
Dual stimulus-responsive dECM cryogel sequentially regulate bone microenvironment for one-step surgical therapy of chronic osteomyelitis.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Curcumin-releasing oxidized konjac/GelMA hydrogel for ROS-mediated suppression of postoperative prostate cancer recurrence and metastasis.International journal of pharmaceutics: X · 2026Article
- Functionalized GelMA-based hydrogels for osteoimmunomodulation and bone regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Sequential polarization of macrophages: an immunomodulatory strategy for novel bone repair materials.Regenerative biomaterials · 2026Review
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Authors and funding
6 authors.
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Abstract
Combining disinfection and bone regeneration in a one-step treatment is of significant clinical importance for chronic osteomyelitis, yet it remains a considerable challenge. To address this, we developed a dual stimulus-responsive decellularized extracellular matrix (dECM) cryogel (GC-dECM@CPN). The cryogel is composed of methacrylate gelatin (GelMA), carboxymethyl chitosan (CMCS), dECM, and temperature-sensitive phase-transition copper peroxide nanoparticles (CPNs). During the infection phase of chronic osteomyelitis, the cryogel exhibits a strong photothermal conversion efficiency under near-infrared (NIR) light irradiation, triggering the release of CPNs to perform chemodynamic therapy (CDT) in the acidic, infected environment. This process enhances macrophage polarization toward the M1 phenotype, promoting the phagocytosis of residual bacteria. Following bacterial eradication, the dECM within the cryogel facilitates the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts while reprogramming macrophages into the M2 phenotype, thereby establishing a conducive environment for bone regeneration. The GC-dECM@CPN cryogel exhibited desirable therapeutic efficacy in both
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