ArticleMolecular therapy. Oncology2025
TREM-1 as a novel immunotherapeutic target to treat pancreatic ductal adenocarcinoma.
Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Unravelling the pathogenesis and therapeutic approaches of pancreatic ductal adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting.Frontiers in immunology · 2026Review
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Authors and funding
11 authors.
Funding
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Abstract
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is highly aggressive with limited curative options, primarily surgical resection. However, only about 20% of the tumors are resectable at diagnosis. Immunotherapies have largely failed in PDAC due to its immunosuppressive tumor microenvironment (TME). This study explores the potential of triggering receptor expressed on myeloid cells 1 (TREM-1) activation in altering the TME and enhancing tumor immunity in PDAC. Using the Pan02 mouse model and single-cell RNA sequencing (scRNA-seq), we found that intra-tumoral TREM-1 activation significantly reduced Pan02 tumor growth, an effect absent in
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