ReviewClinical, cosmetic and investigational dermatology2025
Intralesional Botulinum Toxin A for Keloid Treatment: A Review of Efficacy, Safety, and Clinical Applications.
Review in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Impact of Perceived Teacher Emotional Support on Student Learning: A Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2026Review
- Targeting macrophage function with botulinum toxin: a novel translational strategy for preventing and treating pathological scars.Postepy dermatologii i alergologii · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Keloids are fibroproliferative disorders characterized by excessive scarring, functional impairment, and aesthetic concerns. Despite the availability of various treatments, recurrence rates remain high, highlighting the need for alternative therapies with favorable safety profiles. Botulinum toxin A (BTX-A) has emerged as a potential option for keloid treatment; however, its therapeutic role is still not fully elucidated. The aim of this study was to evaluate the efficacy and safety of BTX-A in the treatment of keloids through a structured review of available literature. Methods: This literature review was conducted from three scientific databases: PubMed, Scopus, and Cochrane. The following keywords used were "botulinum toxin", "BTX-A", "botulinum toxin A", and "keloids". Original studies published in English between 2014 and 2024 that involved human subjects and investigated the use of BTX-A in the treatment of keloids were included. Results: A total of eleven randomized controlled trials were included in this review. Of these, eight studies reported statistically significant improvements in keloid characteristics such as height, pliability, and vascularity following intralesional BTX-A treatment, as measured by validated scales like the Vancouver Scar Scale (VSS). Two studies demonstrated comparable efficacy between BTX-A and intralesional triamcinolone acetonide (TAC). Adverse events were rare and generally limited to mild local reactions. In addition, BTX-A has been shown to be safe for use as a keloid therapy even in the pediatric population. Conclusion: BTX-A showed satisfactory efficacy and safety. In addition, BTX-A showed significant improvement in subjective symptoms in keloid lesions, making BTX-A a promising alternative option for keloid therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.