ArticleExperimental biology and medicine (Maywood, N.J.)2025
Association between systemic immune-inflammation index and 10-year risk of cardiovascular disease in the United States (NHANES 1999-2018).
Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis.Medicine · 2026Article
- Association Between the Aggregate Index of Systemic Inflammation and Non-Dipper Blood Pressure Pattern in Hypertensive Patients with Type 2 Diabetes Mellitus.Journal of inflammation research · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the systemic immune-inflammation index (SII) and the risk of developing cardiovascular disease (CVD) over the next 10 years in the United States is largely unknown. The aim of this study is to assess the association between SII and 10-year CVD risk. This population-based cross-sectional study included 9901 participants aged between 30 and 74 from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The 10-year CVD risk was calculated using the Framingham cardiovascular risk score (FRS). The Pearson test, generalized linear model (GLM) and restricted cubic splines (RCS) were used to analyze the associations between SII and the FRS. Based on the total population, the Pearson test and GLM revealed that there were positive relationships between Ln-transformed SII (Ln (SII)) and the FRS. After adjusting for confounding factors, the odds ratio (OR) for the FRS was 1.52 (95% confidence interval [CI]: 1.12-2.06) per unit increment in Ln (SII) (
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