Advanced NSCLC with leptomeningeal metastasis: Diagnostic and therapeutic challenges: A case report.

Gana Odeh, Dana Foqha, Mohammed Abu Kamesh, Jihad Hamaida

Abstract readCase Reports

In one paragraph

Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gana OdehMedical Intern, An-Najah National University Hospital, Nablus, Palestine.

Dana FoqhaMedical Intern, An-Najah National University Hospital, Nablus, Palestine.

Mohammed Abu KameshRadiology Resident, Department of Radiology, An-Najah National University Hospital, Nablus, Palestine.

Jihad HamaidaRadiologist Consultant, Head of Radiology Department, An-Najah National University Hospital, Nablus, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer, particularly non-small lung cancer (NSCLC), is one of the most common malignant tumors worldwide and is associated with high mortality in advanced stages. Lung adenocarcinoma is the most frequent NSCLC subtype. Among these common metastatic sites, brain metastases and leptomeningeal metastases have a particularly debilitating impact on patients' survival and quality of life. We describe the clinical course of a 43-year-old man with stage IV lung adenocarcinoma who developed crizotinib-induced pancreatitis and leptomeningeal metastases, both are rare. Imaging of the brain was done due to the development of neurological symptoms and demonstrated metastatic leptomeningeal enhancement. The patient's condition continued to worsen and resulted in sudden cardiac arrest. This case demonstrates a rare complication of NSCLC-leptomeningeal metastasis-and the importance of a multidisciplinary team approach in managing advanced NSCLC.

Indexed as

Brain metastasisCrizotinibLeptomeningeal metastasisLung cancerNSCLC

Identifiers

PMID40917487

DOI10.1016/j.radcr.2025.08.004

PMCPMC12409375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.