ReviewMagnetic resonance letters2024
Progress in magnetic resonance imaging of the glymphatic system.
Review in Magnetic resonance letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Collapse of Brain Clearance: Glymphatic-Venous Failure, Aquaporin-4 Breakdown, and AI-Empowered Precision Neurotherapeutics in Intracranial Hypertension.International journal of molecular sciences · 2025Review
- Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives.Epilepsy currentsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of cerebral interstitial fluid (ISF) and cerebrospinal fluid (CSF). GS occurs through a normal exchange within perivascular space (PVS), facilitating the elimination of metabolic wastes generated by nerve cells from the brain. Therefore, the GS is mainly responsible for the removal of metabolic waste. Reduced GS activity has been observed to be associated with central nervous system disorders such as cerebral small vessel disease (CSVD) and neurodegenerative diseases. Its activity is expected to be an indicator for diagnosing diseases and predicting their prognosis. This review introduces the magnetic resonance imaging (MRI) technology related to the GS suitable for clinical use and the difference in the system's activity in normal and abnormal states. Through a summary of previous research, imaging methods suitable for monitoring the activity of the GS in the clinic were proposed, and their diagnostic effect on different brain disorders was analyzed. This review aims to clarify ideas for the clinical translation of basic research focusing on GS and provide future clinical research directions and perspectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.