ArticleFrontiers in public health2025
Mental health among healthcare workers during COVID-19: a study to oversee the impact of the risk perception and relationship with inflammation from blood-based extracellular vesicles.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Psychological and Physiological Assessment of Distress Among Public Healthcare Workers During Pandemic Control Efforts.Healthcare (Basel, Switzerland) · 2026Article
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5 authors.
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Abstract
Introduction: Preventive measures have been implemented in hospitals during COVID-19, but how these guidelines affected mental health among healthcare workers (HCWs) remains to be determined. On another note, reliable psychological and blood-based markers are needed to promptly identify HCWs at-risk to develop distress. Extracellular vesicles (EVs) originating from brain cross the blood-brain barrier and are detectable in blood, giving them a highly valuable potential for biomarker discovery. In HCWs with or without psychological distress, we investigated how perceived stress during COVID-19 impacted mental health. We then longitudinally evaluated the inflammatory cargo from neuron-, astrocyte-, and microglial-derived EVs that may be associated with psychological distress. Methods: Our prospective study that included an initial visit (02/2021-08/2021), and two follow-up visits 3 and 6 months later (last visit; 03/2022). HCWs ( Results: Onset of psychological distress was associated early hyperarousal. Moreover, severe distress was associated with increased astrocyte-specific levels of anti-inflammatory interleukin-10 and pro-inflammatory interferon-ɣ. Discussion: Our findings-that need to be replicated in larger studies-suggest that early hyperarousal may be predictive of later onset of psychological distress in HCWs. They also unravel a novel area of biomarker discovery study in psychiatry as inflammation from brain-derived EVs could help targeting "at-risk" individuals.
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