SynthesisFrontiers in public health2025
Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review.The journal of nutrition, health & aging · 2026Pooled it
- Effects of Heat-KilledNutrients · 2026Trial
- Associations of insulin-like growth factor-1 with gait vigor, symmetry, and stability metrics measured by wearable sensors in older adults.BMC geriatrics · 2026Article
- Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review).International journal of molecular medicine · 2026Review
- A Cross-Sectional Analysis of Musculoskeletal and Functional Outcomes in Patients with Pituitary Disorders: Frailty and Sarcopenia.Journal of clinical medicine · 2026Article
- Proteomics of aging: biomarkers for physiological systems and diseases.Frontiers in aging · 2026Review
- The Impact of K-1 Kickboxing Tournament Fights on Growth Hormone, IGF-1, and Insulin Levels: Preliminary Findings from a Pilot Study in Elite Athletes.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Insulin-like growth factor-1 (IGF-1) is thought to play an important role in regulating skeletal muscle mass and function, with its decline potentially linked to age-related frailty and sarcopenia. Given the limitations of pharmacological and nutritional interventions, exercise may serve as a potential non-pharmacological strategy to modulate IGF-1 levels. The purpose of this study is to systematically evaluates the effects of exercise interventions on serum IGF-1 levels in older adults with frailty and/or sarcopenia using a meta-analysis approach. Methods: A systematic search was conducted in PubMed, Web of Science, Cochrane Library, EMBASE and Scopus (from inception to July 2025) to identify randomized controlled trials (RCTs) investigating the impact of exercise interventions on serum IGF-1 levels in older adults with frailty and/or sarcopenia. Data were analyzed using RevMan 5.4 and Stata 15.1, with standardized mean differences (SMD) and 95% confidence intervals (95% CI) calculated via a random-effects model. The protocol was registered with PROSPERO (CRD420251085472). Results: A total of 11 studies (comprising 16 RCTs) were included, involving 604 participants (intervention group: 314; control group: 290), age range: 63.6 to 85.8 years old. Meta-analysis revealed that exercise interventions significantly increased serum IGF-1 levels in older adults with frailty and/or sarcopenia (SMD = 0.42, 95% CI: 0.23-0.60, Conclusion: Exercise intervention can effectively increase serum IGF-1 concentrations in older adults with frailty and/or sarcopenia. The research results may provide key evidence-based basis for clinical non-pharmacological interventions. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251085472.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.