Evidence map›Paper›PMID 40917376›Full record

ArticleGhana medical journal2021

Dapsone-induced drug reaction with eosinophilia and systemic symptoms (DRESS): the role of the primary care physician.

Blessing O Akor, Bob Ukuonu, Alexander A Akor, Ojonugua A Ameh, Theresa Otu, Thairu Yunusa, Onyinye Onyeadi, Grace Lakai

Abstract readCase Reports
In one paragraph

Article in Ghana medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Blessing O AkorDepartment of Fam. Medicine, University of Abuja Teaching Hospital, P.M.B 228, Abuja-F.C.T. Nigeria.
Bob UkuonuDepartment of Int. Medicine, University of Abuja, P.M.B 117, Abuja, Nigeria.
Alexander A AkorDepartment of Int. Medicine, University of Abuja, P.M.B 117, Abuja, Nigeria.
Ojonugua A AmehDepartment of Int. Medicine, University of Abuja, P.M.B 117, Abuja, Nigeria.
Theresa OtuDepartment of Haematology, University of Abuja, P.M.B 117, Abuja, Nigeria.
Thairu YunusaDepartment of microbiology, University of Abuja, P.M.B 117, Abuja, Nigeria.
Onyinye OnyeadiDepartment of Fam. Medicine, University of Abuja Teaching Hospital, P.M.B 228, Abuja-F.C.T. Nigeria.
Grace LakaiDepartment of Pharmacy, University of Abuja Teaching Hospital, P.M.B 228, Abuja-F.C.T. Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe adverse drug reaction with debilitating morbidity and high mortality. The interest of this presentation is to report a case of dress and the role of the healthcare coordinator (family physician) in early diagnosis, prompt treatment and coordination of care. We report a case of a 32-year-old male who was wrongly commenced on Dapsone for seizure disorder from a primary health centre. He presented two months later with a month history of severe dry cough, pleurisy, intermittent breathlessness and high-grade fever. He had a generalized pruritic rash with erythema and desquamation. There was marked oedema of the face and feet with generalized lymphadenopathy. He was jaundiced with tender hepatomegaly. He had dark coloured urine and a trace of proteinuria but normal renal function. There was marked leukocytosis (35*10 Funding: None declared.

Indexed as

DapsoneDrug ReactionEosinophiliaPrimary CareSystemic Symptoms

Identifiers

PMID40917376
PMCPMC12410027

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