Evidence map›Paper›PMID 40917364›Full record

Observational studyFrontiers in endocrinology2025

Impact of gonadotropin genetic profile and ovarian reserve on controlled ovarian stimulation: data from prospective cohort of the GENOCS trial.

Alessandro Conforti, Daniele Santi, Adolfo Allegra, Mario Mignini Renzini, Angelo Marino, Claudio Brigante, Roberta Iemmello, Valeria Stella Vanni, Agnese Rebecchi, Laura Privitera and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessandro Conforti *Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Daniele Santi *Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Adolfo AllegraReproductive Medicine Unit, ANDROS Day Surgery Clinic, Palermo, Italy.
Mario Mignini RenziniBiogenesi Reproductive Medicine Centre, Istituti Clinici Zucchi, Monza, Italy.
Angelo MarinoReproductive Medicine Unit, ANDROS Day Surgery Clinic, Palermo, Italy.
Claudio BriganteBiogenesi Reproductive Medicine Centre, Istituti Clinici Zucchi, Monza, Italy.
Roberta IemmelloBiogenesi Reproductive Medicine Centre, Istituti Clinici Zucchi, Monza, Italy.
Valeria Stella VanniGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Agnese RebecchiIstituto Eugyn, Modena, Italy.
Laura PriviteraGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Samantha SperdutiUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Livio CasariniUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Ilma Floriana CarboneUnit of Obstetrics, Department of Woman, Child and Neonate, Mangiagalli Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Manuela SimoniUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Carlo AlviggiDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Enrico PapaleoGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Several studies indicate that a specific genotype profile could influence ovarian sensitivity to exogenous gonadotropin. However, most of the previous studies were observational and retrospective and thereby more prone to bias. The aim of this study was to evaluate the impact of gonadotropin single nucleotide polymorphisms (SNPs) on the outcomes of Method: A multicenter, longitudinal, prospective, interventional cohort study was carried out in four clinical centers of medically assisted reproduction from August 2016 to November 2018. Only expected normo-responder women, estimated through standardized-computerized antral follicle count (AFC), stimulated with a fixed 150 IU daily dose of recombinant follicle-stimulating hormone (FSH), were included. The study population consisted of infertile normo-gonadotropic patients, aged between 34 and 39, at their first OS, with normal ovarian reserve (AFC between 8 and 16) measured with 3D automated ultrasonography and undergoing standardized OS protocol. Results: One hundred nineteen patients were enrolled, and the following five SNPs were studied ( Discussion: Based on our results, the combination of specific genetic variants could impact ovarian sensitivity to gonadotropin. This research adds to the controversy in the literature regarding the effect of genetic variants in IVF and ovarian response.

Indexed as

GonadotropinsInfertility, FemaleOvarian ReserveOvulation InductionPolymorphism, Single NucleotideReceptors, FSHAdultFemaleFertilization in VitroFollicle Stimulating HormoneGenotypeHumansLongitudinal StudiesPregnancyPregnancy RateProspective StudiesFollicle Stimulating HormoneFSHR protein, humanGonadotropinsLHCGR protein, humanReceptors, FSHReceptors, LHARTgenetic variantsIVF/ICSIovarian stimulationpharmacogenomicpolymorphisms

Identifiers

PMID40917364
PMCPMC12411160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.