ArticleIndian journal of endocrinology and metabolism
Deciphering Bone Microarchitecture in Diabetic Charcot Neuroarthropathy of Foot: A Case Control Study.
Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Charcot neuroarthropathy (CNO) of foot characterised by an increased bone turnover denoted by serological markers of bone resorption. However, histological characteristics of foot bones in people with CNO are not well elucidated. Methods: The foot bone samples were collected from patients who had either surgical reconstruction or below-knee amputations for chronic CNO foot ( Results: The mean age of participants in the CNO group was 61.6 ± 5.0 and 62.9 ± 6.5 years in diabetic neuropathy group with duration of diabetes 13.1 ± 6.8 and 14.1 ± 9.1 years with HbA1c of 7.6 ± 1.8% and 8.7 ± 2.6 in group A and B, respectively. We observed that normal bone trabeculae were 15% (10-37.5) in group A and 60% (47.5-82.5) in group B as compared to controls ( Conclusions: There is an increased bone resorption in CNO causing thinning of bone trabeculae secondary to increased osteoclast numbers and Howship's lacunae in CNO of foot. Anti-resorptive therapies that target osteoclast activity may be an appealing treatment option for diabetic CNO of foot.
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