Evidence map›Paper›PMID 40917304›Full record

Trial reportDepression and anxiety2025

Vortioxetine Improves Brain Glymphatic System Function, Functional Connectivity, and Cognitive Functions in Major Depressive Disorder.

Zixuan Guo, Xinyue Tang, Shuming Zhong, Guanmao Chen, Pan Chen, Chao Chen, Ruoyi Chen, Li Huang, Yanbin Jia, Ying Wang

Abstract readClinical Trial
In one paragraph

Trial report in Depression and anxiety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Diffusion tensor imaging in chronic tension-type headache.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zixuan GuoMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0002-6772-1131
Xinyue TangMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Shuming ZhongDepartment of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China.
Guanmao ChenMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Pan ChenMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Chao ChenMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Ruoyi ChenMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Li HuangMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Yanbin JiaDepartment of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0002-6104-8097
Ying WangMedical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0002-0388-4177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antidepressive AgentsBrainCognitionDefault Mode NetworkGlymphatic SystemMajor Depressive DisorderNerve NetVortioxetineAdultConnectomeDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedAntidepressive AgentsVortioxetinecognitive functionsglymphatic systemmajor depressive disorderresting-state MRIvortioxetine

Identifiers

PMID40917304
PMCPMC12413946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.