ArticleTurkish journal of biology = Turk biyoloji dergisi2025
Different hypoxic response of human
Article in Turkish journal of biology = Turk biyoloji dergisi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Cell-Type-Dependent Responses to Oleuropein in MDA-MB-231 Breast Cancer Cells and HUVECs.Cell biochemistry and biophysics · 2026Article
- The Dual Role of TGF-β and Hypoxia on MMP14-Mediated Invasion in PC3 Cells.Cell biochemistry and biophysics · 2026Article
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4 authors.
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Abstract
Background/aim: A number of carbonic anhydrase (CA) family proteins have been implicated in cancer. They contribute to the hypoxic microenvironment. CAVII is often downregulated in colorectal carcinoma and it has been associated with increased tumor size, node metastasis, and adverse clinical outcomes. In this study, we aimed to investigate the effect of hypoxia on CAVII protein in human colon cancer and prostate cancer cells. In addition, the regulation of Materials and methods: CAVII expression was analyzed in different cell lines such as human colon cancer (SW480 and HT-29), human prostate cancer (PC3 and LNCaP), human hepatocellular carcinoma (Hep3B) and Human umbilical vein endothelial cells (HUVEC). HT-29 and LNCaP cell lines were subjected to a chemical hypoxia model with CoCl Results: We found that CAVII expression decreased under hypoxic conditions in HT-29, but conversely, increased in LNCaP cells at the mRNA and protein level. In the hypoxia model in Conclusion: The results emphasize the necessity of addressing hypoxic regulation in different cell and organism groups in cancer and healthy conditions for CA family members that change under physiological and pathophysiological conditions. Postgenomic studies are important to better understand the evolution of these ancient enzymes.
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