Evidence map›Paper›PMID 40917297›Full record

ArticleTurkish journal of biology = Turk biyoloji dergisi2025

miR-9-5p alleviates the development of abdominal aortic aneurysm by regulating the differentiation of CD4

Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Turkish journal of biology = Turk biyoloji dergisi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Hongfu Liu *Department of Anatomy, School of Basic Medicine, Binzhou Medical University, Yantai, Shangdong Province, China.ORCID https://orcid.org/0009-0004-5913-991X
Jinyi Zhang *Xu Rongxiang Regenerative Medicine Research Center, Binzhou Medical University, Yantai, P.R. China.ORCID https://orcid.org/0009-0000-4143-0603
Lubin Li *Department of Vascular Surgery, Yantai Yuhuangding Hospital, Yantai, Shangdong Province, China.ORCID https://orcid.org/0000-0003-2677-5819
Benxiang YuDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, Yantai, Shangdong Province, China.ORCID https://orcid.org/0009-0005-5446-8316
Chunlei ZhangDepartment of Anatomy, School of Basic Medicine, Binzhou Medical University, Yantai, Shangdong Province, China.ORCID https://orcid.org/0009-0002-0210-3516
Wenqiang NiuDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, Yantai, Shangdong Province, China.ORCID https://orcid.org/0009-0004-9969-8054
Yawen ChengXu Rongxiang Regenerative Medicine Research Center, Binzhou Medical University, Yantai, P.R. China.ORCID https://orcid.org/0009-0009-4178-8491
Hengyang DongDepartment of Vascular Surgery, Yantai Yuhuangding Hospital, Yantai, Shangdong Province, China.ORCID https://orcid.org/0000-0001-6352-669X
Yukun ZhangXu Rongxiang Regenerative Medicine Research Center, Binzhou Medical University, Yantai, P.R. China.ORCID https://orcid.org/0009-0005-2425-5491
Xinlin LuoXu Rongxiang Regenerative Medicine Research Center, Binzhou Medical University, Yantai, P.R. China.ORCID https://orcid.org/0009-0004-4873-5601
Yanlian XiongXu Rongxiang Regenerative Medicine Research Center, Binzhou Medical University, Yantai, P.R. China.ORCID https://orcid.org/0000-0001-5178-8932
Yueming WangXu Rongxiang Regenerative Medicine Research Center, Binzhou Medical University, Yantai, P.R. China.ORCID https://orcid.org/0000-0003-1375-8737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Abdominal aortic aneurysm (AAA), a gradual segmental dilatation of the abdominal aorta, is associated with a high mortality rate. The pathophysiological molecular mechanisms underlying AAA remain unclear. In recent years, changes in miRNA levels have been reported to be involved in the development and treatment of AAA. This study aimed to investigate the potential targets and underlying mechanisms of miR-9-5p in attenuating AAA progression by modulating the inflammatory response. Materials and methods: Biochemical kits were used to measure the levels of inflammatory factors, antioxidant enzyme activity, and serum oxidative stress in normal and AAA model mice. miR-9-5p overexpression was achieved by transfecting miR-9-5p mimics into CD4 Results: Compared with that in the control group, miR-9-5p expression in CD4 Conclusions: By controlling the interaction between the Nrf2 and NF-κB signaling pathways, miR-9-5p mediates the differentiation of CD4

Indexed as

Abdominal aortic aneurysmCD4+ T cellsmiR-9-5pNrf2oxidative stress

Identifiers

PMID40917297
PMCPMC12410872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.