ArticleBiomedical engineering letters2025
Antibacterial and anticancer activity of multifunctional iron-based magnetic nanoparticles against urinary tract infection and cystitis-related bacterial strains and bladder cancer cells.
Article in Biomedical engineering letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study investigates the antibacterial and anticancer activity of previously reported iron oxide (Fe
methodTo investigate the potential applicability of the synthesized NPs as therapeutic agents for image-based photodynamic BC therapy, their photodynamic anticancer activity was analyzed and the mechanisms of cell death in T-24 cells treated with these NPs were assessed qualitatively and quantitatively through atomic absorption spectroscopy, fluorescence imaging, and transmission electron microscopy.
resultsThe effective localization of FCF NPs in T-24 cells were confirmed, validating their excellent cellular fluorescence and magnetic resonance imaging capabilities. Moreover, the FCF NPs exhibited excellent anticancer activity via distinct mechanisms of cell death; they induced apoptotic cancer cell death by strongly upregulating apoptosis-related mRNA genes, such as Bcl-2-interacting killer, growth arrest DNA damage-inducible protein 45 beta, and Caspase-3, -6, and -9. Furthermore, the FCF NPs showed significant antibacterial activity against
conclusionFCF NPs effectively induce cancer cell death, show excellent photodynamic anticancer efficacy against BC cells, and exhibit potent antibacterial activity against uropathogenic bacterial strains via PDT, exhibiting high potential for application in versatile imaging-based diagnostics and therapeutics in BC treatment and urinary tract infection management. However, prior to their clinical application, in vivo studies using animal models are required to validate these biological and physiological effects.
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