ArticleAmerican journal of hypertension2026
Dynamical Regulation of Blood Pressure and Cognitive Function.
Joshua Sweigert, Tara Gruenewald, Margie Lachman, Teresa Seeman, Maxine Weinstein, Tse-Hwei Choo, Martina Pavlicova, Ramakrishna Mukkamala, Richard P Sloan
Abstract read
In one paragraphArticle in American journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Joshua SweigertDivision of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Tara GruenewaldDepartment of Psychology, Chapman University, Orange, California, USA.
Teresa SeemanDivision of Geriatrics, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Maxine WeinsteinCenter for Population and Health, Georgetown University, Washington, District of Columbia, USA.
Tse-Hwei ChooDivision of Behavioral Medicine, New York State Psychiatric Institute, New York, New York, USA.
Martina PavlicovaDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
Ramakrishna MukkamalaBioengineering Department, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Richard P SloanDivision of Behavioral Medicine, New York State Psychiatric Institute, New York, New York, USA.ORCID 0000-0003-4999-9209 Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MU19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8MSTATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6MZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MIntegrative Pathways to Cognitive, Affective, and Brain HealthU01AG077928 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson, MARGIE E LACHMAN · 2022 to 2026
$17.7MWIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9MPsychosocial Factors and Aging: Resting/Reflexive Cardiovascular ControlR21AG044260 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SLOAN, RICHARD P · 2013 to 2014
$470kBlood Pressure Variability ProjectGeneral Clinical Research Centers Program UL1TR000427Georgetown University M01-RR00865NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR002373NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR023942NIA NIH HHS M01-RR023942NIA NIH HHS P01 AG020166NIA NIH HHS P01-AG020166NIA NIH HHS R21 AG044260NIA NIH HHS U01 AG077928NIA NIH HHS U19 AG051426NIH HHS M01-RR023942NIH HHS NIH/NIA R21 AG044260NIH HHS P01-AG020166The Nathaniel Wharton FundUniversity of California, Los AngelesUniversity of Wisconsin UL1TR001881
6 · The paper itselfAbstract
backgroundBlood pressure (BP) is not steady. It varies over intervals from months to consecutive cardiac cycles, and this variation contains meaningful information beyond mean BP. Variability over multiple clinic visits (VVV-BP) and during 24-h ambulatory monitoring (ABPV) is positively related to risk of stroke and coronary artery disease and negatively associated with cognitive performance. Beat-to-beat BP variation, often quantified as low frequency variability (0.04-0.15 Hz, LF-BPV), is less well-studied. Here, we examine the relationship between LF-BPV and cognitive outcomes in 1953 participants from the Midlife in the US study.
methodsParticipants completed the Brief Test of Adult Cognition by Telephone from which we derived episodic memory (EMF) and executive function (EFF) factors and a composite index. With participants in the seated position, the continuous BP signal was recorded noninvasively with a Finometer. The resultant time series was submitted to Fourier-based spectral analysis to compute LF-BPV. Linear regression models estimated the associations with cognitive indices.
resultsSystolic (LF-SBPV) and diastolic (LF-DBPV) were positively associated with EFF (b = 0.073 ± 0.033, P = 0.02), EMF (b = 0.079 ± 0.036, P = 0.04), and the composite index (b = 0.101 ± 0.035, P = 0.004) after adjustment for age, sex, education, and income. Findings were similar for LF-DBPV.
conclusionsThis positive association is consistent with evidence demonstrating that LF blood pressure variability contributes to increased delivery of oxygenated blood to the brain and clearance of metabolic and cellular waste via the brain's glymphatic system and intramural periarterial drainage pathway, both of which contribute to superior cognitive performance.
Indexed as
Blood PressureCognitionHypertensionAgedBlood Pressure Monitoring, AmbulatoryExecutive FunctionFemaleHumansMaleMemory, EpisodicMiddle AgedTime FactorsUnited Statesblood pressureblood pressure variabilitycognitive functionhypertensionobservational study
Identifiers
PMID40916949
PMCPMC12919557
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