Evidence map›Paper›PMID 40916684›Full record

ArticleDiabetes & metabolism journal2026

Pancreatic Islet Transplantation in Extrahepatic Sites: Evaluation of the Venous Sac in Large Mammal Models.

Giorgi Kenchadze, Ivane Abiatari, Antonello Pileggi, Norma S Kenyon, Dora M Berman, R Damaris Molano, Konstantine Gogichaishvili, Revaz Otarashvili, Anzor Tchavtchavadze, Teona Midelashvili and 4 more

Abstract read
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Article in Diabetes & metabolism journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giorgi KenchadzeInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Ivane AbiatariInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Antonello PileggiCell Transplant Center, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Norma S KenyonCell Transplant Center, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Dora M BermanCell Transplant Center, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
R Damaris MolanoCell Transplant Center, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Konstantine GogichaishviliInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Revaz OtarashviliInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Anzor TchavtchavadzeInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Teona MidelashviliInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Mariam MotsikulashviliInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Camillo RicordiCell Transplant Center, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Thierry BerneyInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Ekaterine BerishviliInstitute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.

Funding

Diabetes Research Institute FoundationRustaveli National Science Foundation of Georgia FR-24-26316Swiss National Science Foundation 152473
6 · The paper itself

Abstract

backgruoundThe long-term clinical efficacy of intraportal islet transplantation is hampered by islet loss due to inflammation, oxidative stress, and insufficient vascularization. This study explores the venous sac as an alternative implantation site for islet transplantation in large animal models.

methodsAn immunosuppressed, diabetic cynomolgus monkey received allogeneic islet implants in its mesenteric venous sac, with metabolic assessments over 112 days. Dogs underwent islet autotransplantation into various venous sacs, with their glycemic control and other metabolic parameters monitored for 1 month.

resultsIn a nonhuman primate, the mesenteric venous sac site improved glycemic control over a 3-month period, followed by destabilization of graft function. Histological studies revealed healthy islets. The lack of mononuclear cell infiltrate suggested no signs of graft rejection. Saphenous venous sacs in dogs showed superior glycemic control, reduced insulin requirements, and maintained C-peptide levels, comparable to intraportal transplantation. Histological analyses confirmed islet preservation and graft vascularization in saphenous venous sacs.

conclusionThis study provides preclinical evidence in support of the venous sac as a valuable extrahepatic location for pancreatic islet implantation. We found that the saphenous vein is a more effective site for islet engraftment than the mesenteric vein. This study offers potential benefits for improving the success rates of clinical islet transplantation.

Indexed as

Diabetes Mellitus, ExperimentalIslets of LangerhansIslets of Langerhans TransplantationMesenteric VeinsSaphenous VeinAnimalsBlood GlucoseDisease Models, AnimalDogsMacaca fascicularisMaleTransplantation, AutologousBlood GlucoseCell transplantationDiabetes mellitus, type 1DogsIslets of langerhans transplantationModels, animal

Identifiers

PMID40916684
PMCPMC13175704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.