Evidence map›Paper›PMID 40916527›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[2,6-dimethoxy-1,4-benzoquinone alleviates dextran sulfate sodium-induced ulcerative colitis in mice by suppressing NLRP3 inflammasome activation].

Chenfei Liu, Wei Zhang, Yao Zeng, Yan Liang, Mengting Wang, Mingfang Zhang, Xinyuan Li, Fengchao Wang, Yanqing Yang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenfei LiuClinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Wei ZhangClinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yao ZengClinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yan LiangAnhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu 233030, China.
Mengting WangAnhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu 233030, China.
Mingfang ZhangAnhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu 233030, China.
Xinyuan LiAnhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Bengbu 233030, China.
Fengchao WangClinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yanqing YangClinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

National Science Foundation of China 82071775
6 · The paper itself

Abstract

objectivesTo investigate the therapeutic mechanism of 2,6-dimethoxy-1,4-benzoquinone (DMQ) for alleviating dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice.

methodsEighteen male C57BL/6J mice were equally randomized into control group, DSS group and DMQ treatment group. In DSS and DMQ groups, the mice were treated with DSS in drinking water to induce UC, and received intraperitoneal injections of sterile PBS or DMQ (20 mg/kg) during modeling. The changes in body weight, disease activity index (DAI), colon length, spleen weight, and colon histological scores of the mice were examined, and the percentages of Th17 and IFN-γ

resultsIn DSS-treated mice, DMQ treatment significantly alleviated DSS-induced body weight loss, colon shortening, spleen enlargement, and colon inflammation. The DMQ-treated mice showed significantly reduced percentages of Th17 cells and IFN-γ

conclusionsDMQ ameliorates DSS-induced UC in mice by inhibiting NLRP3 inflammasome activation.

Indexed as

BenzoquinonesColitis, UlcerativeInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCaspase 1Dextran SulfateMaleMiceMice, Inbred C57BLTh17 CellsBenzoquinonesCaspase 1Dextran SulfateInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse2,6-dimethoxy-1,4-benzoquinonenatural productsNLRP3 inflammasomeulcerative colitis

Identifiers

PMID40916527
PMCPMC12415577

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.