Evidence map›Paper›PMID 40916521›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Electroacupuncture improves myocardial injury in rats with acute myocardial ischemia by inhibiting HPA axis hyperactivity

Kun Wang, Haiyan Zuo, Jiaojiao Zhang, Xin Wu, Wenhui Wang, Shengbing Wu, Meiqi Zhou

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kun WangPostdoctoral Research Station of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Haiyan ZuoAnhui Provincial Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei 230012, China.
Jiaojiao ZhangAnhui Provincial Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei 230012, China.
Xin WuAnhui Provincial Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei 230012, China.
Wenhui WangAnhui Provincial Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei 230012, China.
Shengbing WuAnhui Provincial Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei 230012, China.
Meiqi ZhouAnhui Provincial Key Laboratory of Meridian Viscera Correlationship, Anhui University of Chinese Medicine, Hefei 230012, China.

Funding

National Natural Science Foundation of China 82004462 and 82274303
6 · The paper itself

Abstract

objectivesTo clarify the role of hippocampal glutamate system in regulating HPA axis in mediating the effect of electroacupuncture (EA) at the heart meridian for improving myocardial injury in rats with acute myocardial ischemia (AMI).

methodsMale SD rats were randomized into sham-operated group, AMI group, EA group, and L-glutamic acid+EA group (

resultsThe rat models of AMI showed significantly decreased LVEF and LVFS and increased serum levels of myocardial enzymes in positive correlation with the HPA axis. Numerous TH- and GAP43-positive cells were observed in the hippocampus, where the expressions of NE and E, neurons colabeled with VGLUT1, VGLUT2 and c-fos, and expressions of VGLUT1, VGLUT2, NMDAR1, NMDAR2B and Glu increased significantly. All these changes were significantly improved by interventions with EA as compared with those in AMI and L-Glutamate+EA groups.

conclusionsIn rats with AMI, EA at the heart meridian can regulate excessive glutamate release in the hippocampus, thereby inhibiting HPA axis hyperactivity and reducing sympathetic nerve activity to protect the myocardial tissue.

Indexed as

ElectroacupunctureGlutamic AcidHippocampusHypothalamo-Hypophyseal SystemMyocardial IschemiaPituitary-Adrenal SystemAnimalsMaleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateGlutamic AcidReceptors, N-Methyl-D-AspartateelectroacupunctureglutamatehippocampusHPA axismyocardial ischemia

Identifiers

PMID40916521
PMCPMC12415584

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