Evidence map›Paper›PMID 40916513›Full record

ArticleStatistics in medicine2025

A Bayesian Multi-Factorial Design and Analysis for Estimating Combined Effects of Multiple Interventions in a Pragmatic Clinical Trial to Improve Dementia Care.

Keith S Goldfeld, Corita R Grudzen, Manish N Shah, Abraham A Brody, Joshua Chodosh, Rebecca Anthopolos

Abstract read
In one paragraph

Article in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keith S GoldfeldDivision of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-0292-8780
Corita R GrudzenDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Manish N ShahBerbeeWalsh Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Abraham A BrodyRory Meyers College of Nursing, New York University, New York, New York, USA.ORCID https://orcid.org/0000-0002-3405-7043
Joshua ChodoshDivision of Geriatric Medicine and Palliative Care, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Rebecca AnthopolosDivision of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-7251-7792

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Statistics CoreU19AG078105 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Abraham Aizer Brody, JOSHUA CHODOSH · 2023 to 2026
$58.3M
Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
NCI NIH HHS P30 CA008748NIA NIH HHS P30 AG066512NIA NIH HHS U19 AG078105NIA NIH HHS U19AG078105
6 · The paper itself

Abstract

Factorial study designs can be important for understanding the effectiveness of interventions when multiple interventions are under investigation. In this design setting, a unit of randomization can be assigned to any combination of interventions. The rationale for taking this kind of approach can vary depending on the specific questions targeted by the research. These questions, in turn, have implications for the way in which the analyses will be conducted. The goal in this paper is to describe how we developed a factorial design along with a Bayesian analytic plan for a large cluster-randomized trial-the Emergency Departments LEading the transformation of Alzheimer's and Dementia care (ED-LEAD) study-focused on improving care for persons living with dementia.

Indexed as

DementiaPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicBayes TheoremEmergency Service, HospitalFactor Analysis, StatisticalHumansResearch DesignBayesian data analysiscluster‐randomized trialfactorial study design

Identifiers

PMID40916513
PMCPMC13137414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.