ArticleJournal of feline medicine and surgery2025
Complex partial seizures with orofacial involvement in 35 cats: MRI changes, cerebrospinal fluid analysis, voltage-gated potassium channel antibodies and survival.
Article in Journal of feline medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Behavioral and autonomic manifestations of suspected focal impaired awareness seizures supported by interictal electroencephalographic findings in three dogs: a case series.Frontiers in veterinary science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesThe objective of this study was to evaluate the occurrence of voltage-gated potassium channel (VGKC) antibodies and the pattern of MRI changes in cats with complex partial seizures with orofacial involvement (CPSOFI), as well as to investigate whether there are factors influencing survival that could be used as prognostic markers in those cats.MethodsCats with CPSOFI were identified retrospectively. The following data were retrieved from the hospital database: signalment, age at first seizure and presentation, the presence of antibodies against VGKC (leucine-rich glioma inactivating factor 1 (LGI1), contactin-associated protein 2 (CASPR2)) and cerebrospinal fluid (CSF) analysis findings. Brain MRI scans were evaluated for T2 and/or fluid-attenuated inversion recovery (FLAIR) hippocampal hyperintensity and hippocampal contrast enhancement by a radiologist. The correlation between being positive for VGKC antibodies and MRI hippocampal hyperintensity was investigated.ResultsSerum antibodies against VGKC were found in 31.4% of cats, with 10/11 positive cats having antibodies against LGI1 and 1/11 against CASPR2. MRI T2/FLAIR hippocampal hyperintensities and T1 contrast enhancement were seen in 57.1% and 27.1% of cats, respectively. There was a weak correlation between those antibodies and MRI changes (phi coefficient 0.12). The following factors did not influence survival on multivariable regression analysis either for all cats together or when the cats that died were evaluated separately: age at first seizure, breed, sex, T2/FLAIR hippocampal hyperintensity, being positive for VGKC antibodies and prednisolone treatment.Conclusions and relevanceThere are no consistent findings on MRI or on testing for VGKC antibodies in all cats with CPSOFI. None of the factors investigated can be used to predict outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.