Evidence map›Paper›PMID 40916421›Full record

ArticleCurrent Alzheimer research2025

The Association between the rs6656401 Locus of the CR1 Gene and Structural Alterations of Brain Effects in Han Chinese Patients with Alzheimer's Disease.

Shu-Yun Zhou, Han-Xiao Lin, Jia-Ming Tang, Qing-Yu Yao, Jia-Wei Hu, Wen-Jun Long, Wen-Zhuo Dai, Tao Ma, Xi-Chen Zhu

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Article in Current Alzheimer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Shu-Yun ZhouDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Han-Xiao LinDepartment of Neurology, the Wuxi No. 2 People's Hospital, Affiliated Wuxi Clinical College of Nantong University, Wuxi, Jiangsu Province, China.
Jia-Ming TangDepartment of Neurology, the Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, China.
Qing-Yu YaoDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Jia-Wei HuDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Wen-Jun LongDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Wen-Zhuo DaiDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Tao MaDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Xi-Chen ZhuDepartment of Neurology, the Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.

Funding

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6 · The paper itself

Abstract

introductionThe complement receptor 1 (CR1) gene is identified as the one closely associated with Alzheimer's disease (AD). However, there has been no exploration of the imaging alterations associated with the CR1 gene in AD patients of the Han population. The purpose of this study is to investigate the association between the rs6656401 mutation and neuroimaging variations in Han AD patients.

methodsWe collected nuclear magnetic resonance images from 101 patients with AD and 98 healthy controls (HC). The subjects in this study, based on the different genotypes of rs6656401, were divided into three groups, with the number of AA, AG, and GG genotypes in the AD group being 1, 17, and 83, and 1, 8, and 89 in the HC group. Data were analyzed using the dominant model. Structural differences in the brain tissue between genotypes at the rs6656401 polymorphic locus were compared using voxel-based morphological analysis, cortical thickness, and graph-theoretic analysis to construct structural networks.

resultsSeven regions (namely, right precuneus, right caudal middle frontal cortical, right rostral middle frontal, right superior frontal, right bankssts, right superior parietal, and right paracentral) were significantly different across CR1 rs6656401 genotypes. The voxel-based morphometry analysis revealed that voxel cluster sizes in the left cerebellum, left superior temporal gyrus, right superior frontal gyrus orbital, right precuneus, and right superior parietal were significantly different in the AA, AG, and GG groups. The degree centrality (Dc) of the left inferior frontal gyrus was significantly greater in the GG group than in the AG group after false discovery rate correction in the structural network analysis. DISCUSSION: This study demonstrates that the rs6656401 AA genotype primarily induces structural alterations in the frontal, temporal, and parietal lobes of AD patients, with significant changes in the right middle frontal gyrus, precuneus, and superior parietal gyrus, along with Dc index alterations in the left inferior frontal gyrus affecting brain network function. Our findings confirm the association between the rs6656401 polymorphism and AD-related brain structural changes, providing the first evidence of these regional alterations in Han Chinese AD cohorts. Future studies will elucidate the locus's pathological mechanism to inform early diagnosis and targeted therapies.

conclusionOur study first indicated that CR1 rs6656401 genotypes significantly influenced the morphological and structural covariate networks in Han AD patients.

Indexed as

Alzheimer DiseaseBrainPolymorphism, Single NucleotideReceptors, Complement 3bAgedAged, 80 and overChinaEast Asian PeopleFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMagnetic Resonance ImagingMaleMiddle AgedCR1 protein, humanReceptors, Complement 3bAlzheimer’s diseaseComplement receptor 1cortical thicknessmagnetic resonance imagesrs6656401structural networks.voxel-based morphological analysis

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PMID40916421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.