Evidence map›Paper›PMID 40916407›Full record

ArticleProtein and peptide letters2025

Essential Role of Non-Conserved α4-His

Chompounoot Imtong, Walairat Bourchookarn, Apichai Bourchookarn, Somsri Sakdee, Hui-Chun Li, Chanan Angsuthanasombat

Abstract read
PubMed Publisher
In one paragraph

Article in Protein and peptide letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chompounoot ImtongBacterial Toxin Research Innovation Cluster, Biophysics Institute for Research and Development (BIRD), Chiang Mai 50210, Thailand.ORCID 0000-0001-5213-7357
Walairat BourchookarnFaculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand.
Apichai BourchookarnFaculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand.ORCID 0000-0003-2755-7020
Somsri SakdeeCenter for Advanced Therapeutics, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakornpathom 73170, Thailand.
Hui-Chun LiDepartment of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Chanan AngsuthanasombatCenter for Advanced Therapeutics, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakornpathom 73170, Thailand.ORCID 0000-0001-7891-9007

Funding

Thailand Science Research and Innovation, Mahidol University BRG-58-8-0002Tzu Chi University, Taiwan TCIRP106001
6 · The paper itself

Abstract

backgroundBacillus thuringiensis Cry toxins are well known for their insecticidal properties, primarily through the formation of ion-leakage pores via α4-α5 hairpins. His

objectiveThis study aimed to investigate the functional importance of Cry4Aa-His

methodsTen His

resultsAll His DISCUSSION: Specific physicochemical properties of residue 178 are critical for optimal larvicidal activity, making it a promising target for engineering more potent mosquito-control toxins.

conclusionHis

Indexed as

AedesBacillus thuringiensisBacterial ProteinsEndotoxinsHemolysin ProteinsHistidineInsecticidesAnimalsBacillus thuringiensis ToxinsEscherichia coliLarvaMolecular Dynamics SimulationMutagenesis, Site-DirectedBacillus thuringiensis ToxinsBacterial ProteinsEndotoxinsHemolysin ProteinsHistidineinsecticidal crystal protein, Bacillus ThuringiensisInsecticidesCry insecticidal proteinshelical hairpinhydrogen bondinglarval toxicitymembrane perturbationstructural integrity.

Identifiers

PMID40916407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.