ArticleCurrent protein & peptide science2026
Evaluation of
Article in Current protein & peptide science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOne to two percent of women worldwide experience recurrent pregnancy loss (RPL), defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation. Genetic factors, including variations in the MATERIALS AND
methodsThis case-control study involved DNA extraction from 300 participants, including 150 recurrent pregnancy loss (RPL) cases and 150 non-recurrent pregnancy loss (NRPL) controls. Polymerase chain reaction (PCR) and Sanger sequencing were used to identify genetic variants. The identified single-nucleotide polymorphisms (SNPs) were analyzed for frequency differences between the RPL and control groups. Additionally, bioinformatics tools were employed to assess the structural impact of the identified mutations on the FOXP3 protein.
resultsSeven novel single-nucleotide polymorphisms (SNPs) were identified, with four SNPs (-11InsT, 206G>A in exon 2, and 433InsT, 726A>T in exon 7), showing significant frequency variations between RPL and NRPL groups. The modeled structures of FOXP3 apo and mutant proteins displayed similar structural features, including a DNA-binding domain. Molecular dynamics simulation studies revealed comparable stability between the apo and mutant forms of FOXP3. DISCUSSION: The identified mutations in the
conclusionThese findings provide new insights into the genetic underpinnings of idiopathic RPL and underscore the importance of genetic testing for a better understanding of this condition.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.