ArticleAnnals of pediatric endocrinology & metabolism2025
Age-related insulin resistance changes in children and adolescents and its impact on the accuracy of diagnosis of metabolic syndrome.
Article in Annals of pediatric endocrinology & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association of Waist Circumference and Body Composition Indices with Insulin Resistance in Prepubertal Children with Obesity.Metabolites · 2026Article
- Discriminative Ability of TyG, TyG-WC, BAI, FGIR, and QUICKI Indexes in Identifying Metabolic Syndrome in a Pediatric Population with Obesity.Metabolites · 2026Article
- Screening for insulin resistance in children with abdominal obesity: sex-specific performance of TyG index, FGIR, and VAI.Physical activity and nutrition · 2026Article
- The cardiometabolic index and miR-29a as related biomarkers for insulin resistance and dysglycemia in adults: insights from the KERCADRS study.Scientific reports · 2026Article
- Assessment of BMI percentages of obesity thresholds and cardiometabolic risk factors in children and adolescents: a retrospective cross-sectional study in Beijing.Lipids in health and disease · 2026Article
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7 authors.
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Abstract
purposeAlthough insulin resistance (IR) varies with age and puberty in children and adolescents, most previous attempts to determine cutoff values for IR indices overlook factor. This study assesses age-related differences in IR index values and evaluates how diagnostic performance varies by age when using a uniform cutoff for diagnosing metabolic syndrome (MetS) without considering age.
methodsWe analyzed age-related differences in IR indices (the homeostatic model assessment of insulin resistance [HOMA-IR], triglyceride-glucose [TyG] index, and triglyceride/high-density lipoprotein cholesterol [TG/HDL-C] ratio) among 1,641 participants in the 2019-2021 Korea National Health and Nutrition Examination Survey. We also examined IR index values for diagnosing MetS in 1,574 participants.
resultsIR indices showed significant age-related variations in group-comparison tests, with a peak at ages 12-13 years in males and 11-13 years in females (P<0.001 for the HOMA-IR, P<0.005 for the TG/HDL-C ratio in both males and females, and P=0.003 for the TyG index in females). Applying a uniform cutoff derived from receiver operating characteristic curve analysis for diagnosing MetS showed substantial age-related variation in diagnostic accuracy, with standard deviation-to-mean ratios of age-specific accuracy of >10% for the HOMA-IR and >5% for the TyG index, while showing minor variation (<5%) for the TG/HDL-C ratio. Using age-specific percentiles for the HOMA-IR (80th of the general population) and TyG index (80th of those without MetS) reduced these variations to <5% while maintaining similar diagnostic performance.
conclusionThis study highlights the importance of age-related variation in IR in children and adolescents.
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