Evidence map›Paper›PMID 40916013›Full record

ReviewCurrent microbiology2025

Gut Microbes and Inflammation: Their Role in Spinal Cord Injury Progression and Secondary Damage.

Jinwang Dong, Tao Xie, Chen Xu, Zhengwei Xu, Dingjun Hao, Liang Dong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinwang Dong *Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tao Xie *Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chen XuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zhengwei XuDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dingjun HaoDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Liang DongDepartment of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China. dongliang-526@163.com.ORCID http://orcid.org/0000-0001-9047-8371

Funding

Xi'an Innovation Capability Strong Foundation Plan - Medical Research Project 22XYJ0002
6 · The paper itself

Abstract

This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation. The gut microbiota, a community of microorganisms inhabiting the intestinal tract, is closely related to the human health. Recent studies have indicated that the disordered gut microbiota was strongly associated with the progression of several diseases, including intestinal inflammation and SCI, in addition, some specific strains may be involved in the development of intestinal inflammation and secondary inflammatory after SCI. These strains promote intestinal inflammation through the production of inflammatory mediators and activation of immune cells. Intestinal inflammation, in turn, further exacerbate spinal cord pathology and secondary inflammatory. In summary, there is an intimate interaction between the intestinal microbiota, intestinal inflammation and SCI, secondary inflammation. An in-depth study of these interaction mechanisms presented here may aid in understanding of SCI occurrence and development and provide new ideas for future therapeutic strategies.

Indexed as

Gastrointestinal MicrobiomeInflammationSpinal Cord InjuriesAnimalsDisease ProgressionDysbiosisHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.