ArticleOsteoarthritis and cartilage2026
Does hsCRP provide insights into an inflammatory phenotype of knee osteoarthritis?
Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.Journal of clinical medicine · 2026Article
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9 authors.
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Abstract
objectivePosthoc analysis of a canakinumab trial showed a risk reduction of joint replacement in participants with cardiac disease and elevated hsCRP (≥2mg/dL). We determined if hsCRP could serve as a marker to identify an inflammatory OA phenotype characterized by intra-articular synovitis.
methodWe used data from the NIH-funded MOST Study, where participants had baseline knee MRIs and hsCRP assays. Inflammation was scored using the Whole Organ MRI Score (WORMS), with presence defined as Hoffa's synovitis or effusion-synovitis score ≥2 in ≥1 of 3 locations. We examined the relationship between hsCRP and inflammation presence using logistic regression, and the average inflammation score with linear regression. Analyses were repeated with hsCRP categorized as ≥2mg/dL vs. <2mg/dL. Cubic spline regression and ROC curve were completed. Analyses were adjusted for age, sex, and body mass index.
resultsOut of 792 participants (mean age 62, 52% female), mean hsCRP was 2.98 mg/dL, with 41% having hsCRP ≥2mg/dL. Inflammation was present in 28% of knees. No association was found between hsCRP levels and inflammation presence (odds ratio 0.99, 95% confidence interval 0.96-1.01) or average score, including with dichotomized hsCRP. Cubic spline regression did not reveal non-linear associations. The ROC curve suggested poor predictive ability of hsCRP to identify knees with inflammation on MRI.
conclusionDespite interest in identifying an inflammatory phenotype in OA, hsCRP levels do not reliably identify knees with inflammation. Further investigation is needed to determine if hsCRP can predict knee response to therapies targeting inflammation not directly related to synovitis.
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