ArticleVirus research2025
Spillover of SARS-CoV-2 to domestic dogs in COVID-19-positive households: A one health surveillance study.
Article in Virus research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Will animal reservoirs give us the next SARS-CoV-2 variant?PLoS pathogens · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is capable of infecting multiple species through human-to-animal spillover. Human to animal spillovers have been documented both in domestic and wild animal species. Due to close contact in shared households, pet dogs may be at increased risk for contracting the SARS-CoV-2 virus from infected individuals in the same household. In this study, we have analyzed serum samples from dogs (n=196) from Pennsylvania during 2021-2022 for the presence of SARS-CoV-2 specific antibodies. The dogs in this analysis included those that were exposed to individuals of the household, who had history of recent SARS-CoV-2 infection, and from dogs with no known history of potential exposure to SARS-CoV-2. Our analysis found a significantly higher seroprevalence (68 %) among the dogs with exposure to SARS-CoV-2 infection from individuals from COVID-19 positive household compared to other dogs. Our study found the overall seroprevalence of 12.24 % among dogs as determined using a surrogate virus neutralization test (sVNT). All sera that were positive by sVNT were also positive by pseudovirus neutralization test (pVNT) except for sera from one dog, likely due to a lower antibody response. The antibody titers using the panel of spike pseudoviruses in pVNT test showed higher titers against the Delta, Gamma and Alpha variants compared to Omicron. We also tested the diagnostic capabilities of a lateral flow assay (LFA) developed by Zoetis by comparing it to sVNT and pVNT. The LFA showed sensitivity and specificity of 85 % compared to sVNT and 75 % compared to the pVNT indicating its potential for field use. These findings provide serological evidence of SARS-CoV-2 spillover to pet dogs and underscore the importance of continued surveillance in companion animals as part of a One Health approach, especially as new viral variants continue to emerge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.