Evidence map›Paper›PMID 40915314›Full record

Observational studyJournal of the peripheral nervous system : JPNS2025

Polyneuropathy in Kidney Transplant Recipients: Accuracy of a New Clinical Diagnostic Scoring System.

Svea Nolte, Naser B N Shehab, Stefan P Berger, Celina Oldag, Ilja M Nolte, Bianca T A de Greef, Fiete Lange, Marco van Londen, Catharina G Faber, Stephan J L Bakker and 3 more

Erratum issued Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the peripheral nervous system : JPNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04664426 (Adapted Modified Toronto Clinical Neuropathy Score and Erasmus Polyneuropathy Symptom Score Validated by Quantitative Sensory Testing and Nerve Conduction Studies for Kidney Transplant Recipients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04664426 completednot on this map

Adapted Modified Toronto Clinical Neuropathy Score and Erasmus Polyneuropathy Symptom Score Validated by Quantitative Sensory Testing and Nerve Conduction Studies for Kidney Transplant Recipients

TypeobservationalSponsorUniversity Medical Center GroningenRan2021 to 2023Enrolled196ConditionsPolyneuropathies
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Svea NolteDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Naser B N ShehabDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Stefan P BergerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Celina OldagDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Bianca T A de GreefDepartment of Neurology, Mental Health and Neuroscience (HHeNS) Research Institute, Maastricht University Medical Center, Maastricht, the Netherlands.
Fiete LangeDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Marco van LondenDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Catharina G FaberDepartment of Neurology, Mental Health and Neuroscience (HHeNS) Research Institute, Maastricht University Medical Center, Maastricht, the Netherlands.
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Pieter A van DoornDepartment of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Harmen R MoesDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-0139-4107
Gea DrostDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPolyneuropathy is highly prevalent among kidney transplant recipients (KTR), underscoring the need for an accurate yet easy-to-perform diagnostic method to improve understanding and enable early identification of treatable cases.

methodsThis study included KTR at least 12 months post-transplant at the University Medical Centre Groningen, the Netherlands. An expert panel assessed polyneuropathy through a structured neurological examination, quantitative sensory testing, and nerve conduction studies. The modified Toronto Clinical Neuropathy Score (mTCNS) was obtained from all participants. Logistic regression analyses with Firth penalization validated the mTCNS components. A new model, the Kidney Transplant Neuropathy Score (KTNS), was developed through stepwise elimination. Diagnostic performance was evaluated with bootstrapped metrics and ROC curve analyses.

resultsAmong 160 KTR, 91 (57%) were diagnosed with polyneuropathy. All 10 mTCNS components were univariably associated with polyneuropathy; numbness (OR = 4.9 [1.8-18.0]), tingling (OR = 2.5 [1.2-5.9]), impaired nociception (OR = 1.5 [1.1-2.2]), and reduced vibration perception (OR = 1.5 [1.0-2.4]) remained independently associated in multivariable analysis. The mTCNS achieved an area under the curve (AUC) in ROC analysis of 0.83 [0.76-0.89]. Two KTNS were derived: the KTNS

interpretationThe mTCNS is a valid diagnostic tool for polyneuropathy in KTR. The KTNS offers a simplified alternative based on key symptoms and sensory tests, with reflex testing included in the KTNS

trial registrationClinicalTrials.gov identifier: NCT04664426.

Indexed as

Kidney TransplantationPolyneuropathiesSeverity of Illness IndexAdultAgedFemaleHumansMaleMiddle AgedNeurologic Examinationkidney transplantationneurological diagnostic techniquespolyneuropathy

Identifiers

PMID40915314
PMCPMC12414581

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.