Evidence map›Paper›PMID 40915156›Full record

Trial reportPsychiatry research2025

Social cognition training improves recognition of individual emotions in schizophrenia disorder.

Samantha Evy Schoeneman Patel, Kristen M Haut, Hyunkyu Lee, Melissa Fisher, Michael F Green, Joseph Ventura, Sophia Vinogradov, Mor Nahum, Christine I Hooker

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatry research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02246426 (TRuSST), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02246426 nacompletednot on this map

TRuSST: Treatment of Social Cognition in Schizophrenia Trial

TypeinterventionalSponsorPosit Science CorporationRan2015 to 2018Enrolled149ConditionsSchizophreniaArmsComputerized plasticity-based adaptive cognitive training, Commercially available computerized training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samantha Evy Schoeneman PatelDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645W. Jackson Blvd. Suite 600, Chicago, IL, USA 60612; Department of Neurological Sciences, Rush University Medical Center, 1725W. Harrison St. Suite 755, Chicago, IL, USA 60612. Electronic address: samantha_patel@rush.edu.
Kristen M HautDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645W. Jackson Blvd. Suite 600, Chicago, IL, USA 60612. Electronic address: kristen_haut@rush.edu.
Hyunkyu LeeDepartment of Research and Development, Posit Science Inc., 160 Pine St., Suite 200, San Francisco, CA, USA 94111. Electronic address: kyu.lee@positscience.com.
Melissa FisherDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, 2450 Riverside Avenue, Minneapolis, MN, USA 55454. Electronic address: mafisher@umn.edu.
Michael F GreenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, USA 90095; VA Greater Los Angeles, 11301 Wilshire Blvd., Los Angeles, CA, USA 90073. Electronic address: mgreen@ucla.edu.
Joseph VenturaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, USA 90095. Electronic address: JVentura@mednet.ucla.edu.
Sophia VinogradovDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, 2450 Riverside Avenue, Minneapolis, MN, USA 55454. Electronic address: svinogra@umn.edu.
Mor NahumSchool of Occupational Therapy, Faculty of Medicine, Hebrew University, PO Box 24026, Mt Scopus, Jerusalem, Israel 9124001. Electronic address: mor.nahum@mail.huji.ac.il.
Christine I HookerDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645W. Jackson Blvd. Suite 600, Chicago, IL, USA 60612. Electronic address: christine_hooker@rush.edu.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
Computerized Social Cognition training for SchizophreniaR44MH091793 · NIMH · POSIT SCIENCE CORPORATION · PI LEE, HYUN KYU · 2014 to 2016
$1.5M
Post-Graduate Research Training Aligned with the NIMH Strategic PlanR25MH115855 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FLEMING, MICHAEL F., GOULDING, EVAN H. · 2019 to 2023
$973k
Research Colloquium for Junior Psychiatrist InvestigatorsR13DA052195 · NIDA · AMERICAN PSYCHIATRIC ASSOC FOUNDATION · PI CLARKE, DIANA ELAINE · 2020 to 2022
$75k
Research Colloquium for Junior Psychiatrist InvestigatorsR13DA060048 · NIDA · AMERICAN PSYCHIATRIC ASSOC FOUNDATION · PI Diana Elaine Clarke · 2024 to 2026
$75k
NCATS NIH HHS UL1 TR002494NCATS NIH HHS UM1 TR004405NIDA NIH HHS R13 DA052195NIDA NIH HHS R13 DA060048NIMH NIH HHS R25 MH115855NIMH NIH HHS R44 MH091793
6 · The paper itself

Abstract

Impaired recognition of angry, fearful, and emotionless (i.e., neutral) faces is associated with poor social functioning among individuals with schizophrenia disorder (SZ). Limited research evaluates how interventions impact these impairments. Computerized social cognition training can improve overall facial emotion recognition in SZ, but it is unclear whether it improves the aforementioned impairments. We report results from a randomized controlled trial (Trial Registration: NCT02246426) evaluating how computerized social cognition training (SCT) impacts recognition of individual emotions in SZ. Ninety-eight individuals with SZ were randomly assigned to one of two internet-based interventions: SCT or a control condition (computer games without social content) (CON). Participants completed 40 sessions of training over 8-12 weeks. Facial emotion recognition was measured with the Penn ER-40 before training, after 20 sessions, and within 8 weeks of completing 40 sessions. Accuracy and reaction times for each emotion (i.e., anger, fear, happy, neutral, and sad) were analyzed. Linear mixed model analyses and t-tests elucidated intervention effects. A significant Group x Time interaction on accuracy was found favoring the SCT group. Only the SCT group improved recognizing fearful and sad faces; the CON group did not. The SCT group had higher accuracy for neutral recognition than the CON group after training. There was no Group x Time interaction on reaction times. We conclude that, because SCT training improves fear and neutral recognition, it has the potential to improve social functioning in SZ. However, interventions need to be further refined to improve anger recognition and emotion recognition reaction times.

Indexed as

EmotionsFacial RecognitionSchizophreniaSocial CognitionSocial PerceptionAdultFacial ExpressionFemaleHumansMaleMiddle AgedCognitive remediationFacial emotion recognitionSchizophreniaSocial cognition

Identifiers

PMID40915156
PMCPMC12548573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.