Evidence map›Paper›PMID 40915090›Full record

ArticleVirology2025

Interferon-γ receptor signaling is critical for balanced immune activation and protection against influenza after vaccination.

Ki-Hye Kim, Hye Suk Hwang, Youri Lee, Yu-Jin Jung, Eun-Ju Ko, Jae Min Song, Sang-Moo Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ki-Hye KimCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Hye Suk HwangCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; Department of Biomedical Science, Sunchon National University, Suncheon, Republic of Korea.
Youri LeeCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Yu-Jin JungCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Eun-Ju KoCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; College of Veterinary Medicine and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju, Republic of Korea.
Jae Min SongCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; Department of Next Generation Applied Sciences, Graduate School, Sungshin Women's University, Seoul, Republic of Korea.
Sang-Moo KangCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. Electronic address: skang24@gsu.edu.

Funding

Seasonal and universal Vaccination in aged populations with pre-existing immunityR01AI154656 · NIAID · GEORGIA STATE UNIVERSITY · PI KANG, SANG-MOO · 2021 to 2025
$2.7M
NIAID NIH HHS R01 AI154656
6 · The paper itself

Abstract

To better understand the contribution of interferon-γ (IFN-γ) receptor signaling to vaccine-induced immunity, we employed A129 (IFN-α/β receptor-deficient) and AG129 (IFN-α/β/γ receptor-deficient) mouse models. AG129 mice induced comparable levels of virus-specific IgG after vaccination with influenza virus H5 hemagglutinin (HA) virus-like particles (VLPs). Vaccinated AG129 mice with HA VLPs exhibited impaired Th1-immune responses, lower hemagglutination inhibition (HAI) titers, increased susceptibility to virus infection, and lower survival rates following influenza virus (H5N1) challenge than vaccinated A129 mice. The AG129 mice also displayed defective germinal center and plasma cell responses, dysregulated lung inflammation with elevated pro-inflammatory cytokines and chemokines, impaired recruitment of monocytes, natural killer cells, and antigen-presenting cells after HA VLP vaccination and virus challenge, compared to A129 mice. Collectively, these findings underscore the critical role of IFN-γ signaling in coordinating effective and balanced immune responses to influenza HA VLP vaccination and conferring protection against virus infection.

Indexed as

Influenza A Virus, H5N1 SubtypeInfluenza VaccinesOrthomyxoviridae InfectionsReceptors, InterferonSignal TransductionAnimalsAntibodies, ViralCytokinesDisease Models, AnimalFemaleHemagglutinin Glycoproteins, Influenza VirusImmunoglobulin GInterferon-gammaInterferon gamma ReceptorMiceMice, KnockoutAntibodies, ViralCytokinesHemagglutinin Glycoproteins, Influenza VirusImmunoglobulin GInfluenza VaccinesInterferon-gammaInterferon gamma ReceptorReceptors, InterferonVaccines, Virus-Like ParticleInfluenza vaccineInnate and adaptive immunityType II IFN receptor

Identifiers

PMID40915090
PMCPMC12476255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.