ArticleEuropean journal of radiology2025
Spatial heterogeneity and distribution of CT-Based pulmonary vascular volumes in chronic thromboembolic pulmonary hypertension.
Article in European journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Clinical research on pulmonary hypertension from a 2025 perspective: a narrative review.Journal of thoracic disease · 2026Review
- Unenhanced CT quantitative vascular morphometry for detecting central pulmonary embolism: a multicenter study.Quantitative imaging in medicine and surgery · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
RATIONALE/
objectivesImage-based vascular biomarkers may help expedite evaluation of chronic thromboembolic pulmonary hypertension (CTEPH), which remains difficult to diagnose despite available effective therapies. We sought to determine if vascular heterogeneity and central redistribution on chest CT differed between CTEPH, pulmonary arterial hypertension (PAH), and control groups. MATERIALS/
methodsWe retrospectively included 108 patients who underwent right heart catheterization and chest CT (2011-2018). Automated CT image analysis was used to calculate volumes of all arteries, all veins, and small arteries/veins (area < 5 mm
resultsOf 108 patients, 21 had CTEPH, 47 had PAH, and 40 were controls. For vascular heterogeneity, we found consistently higher CVs (i.e. greater heterogeneity) in CTEPH vs. controls. For small arterial volume, CV was 0.09 units higher (95 % CI: 0.04-0.14, p = 0.0004) in the CTEPH group in adjusted models. Similarly, CVs were higher in CTEPH vs. PAH (p = 0.001). For vascular redistribution, we found greater central redistribution in CTEPH compared to controls/PAH; for small arterial volume, central-to-peripheral ratio was 1.52 units higher in CTEPH vs. controls (95 % CI: 0.78-2.26, p = 0.0001).
conclusionVolumetric measures of heterogeneity and central distribution of pulmonary vessels can be quantified using CT techniques and may contribute to an image-based signature of CTEPH.
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