Evidence map›Paper›PMID 40914979›Full record

SynthesisOral diseases2026

Effectiveness of Platelet-Rich Fibrin for Temporomandibular Disorders Management: A Systematic and Meta-Analysis.

Júlia Silva Gomes de Araújo, Wellington Luiz de Oliveira da Rosa, Luiz Augusto Duarte Meirelles, Mateus Gaya Dos Santos, Noéli Boscato

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Júlia Silva Gomes de AraújoGraduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.
Wellington Luiz de Oliveira da RosaGraduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.ORCID https://orcid.org/0000-0001-6992-3127
Luiz Augusto Duarte MeirellesGraduate Program in Dentistry, Oral and Maxillofacial Surgery Faculty Clinic, The Ohio State University, Columbus, USA.ORCID https://orcid.org/0000-0002-6840-5210
Mateus Gaya Dos SantosGraduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.
Noéli BoscatoGraduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.ORCID https://orcid.org/0000-0002-3817-1732

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

objectiveThis study systematically reviewed the effect of intra-articular injection (IAI) of platelet-rich fibrin (i-PRF), alone or combined with arthrocentesis or arthroscopy, in managing painful articular temporomandibular disorders (TMD) and improving maximum mouth opening (MMO). MATERIALS AND

methodsA systematic literature search was conducted in five databases, identifying randomized and nonrandomized clinical trials focusing on minimally invasive TMJ interventions using i-PRF. Meta-analyses were performed with a random-effects model for studies reporting similar outcomes, visual analog scale (VAS) scores for pain, and MMO values.

resultsOut of 332 studies identified, 13 met the inclusion criteria for meta-analysis. Within-group comparisons revealed significant pain reduction at 3-6 and 8-12 months for i-PRF alone or combined with arthrocentesis or arthroscopy. MMO values significantly increased using i-PRF alone at 8-12 months, combined with arthrocentesis or arthroscopy at 3-6 and 8-12 months, with no significant increase using i-PRF alone at 3-6 months. Between-group analyses demonstrated that i-PRF combined with arthrocentesis significantly reduced VAS scores and increased MMO values compared to arthrocentesis alone at 3-6 and 8-12 months.

conclusionUsing i-PRF alone or combined with arthrocentesis or arthroscopy is effective in pain reduction and MMO increase.

Indexed as

Platelet-Rich FibrinTemporomandibular Joint DisordersArthrocentesisArthroscopyHumansInjections, Intra-ArticularPain MeasurementRange of Motion, ArticularTreatment Outcomearthrocentesisarthroscopyplatelet‐rich fibrintemporomandibular disordertemporomandibular joint

Identifiers

PMID40914979
PMCPMC13077014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.