Evidence map›Paper›PMID 40914966›Full record

ArticleThe Journal of physiology2025

Exercise-induced arterial hypoxaemia in patients with heart failure with preserved ejection fraction.

Michael G Leahy, James P MacNamara, Andrew R Tomlinson, Denis J Wakeham, Tiffany L Brazile, Abidan Abulimiti, Kevin C Lutz, Benjamin D Levine, Satyam Sarma, Tony G Babb and 1 more

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael G LeahyInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0002-9209-3982
James P MacNamaraInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Andrew R TomlinsonInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0001-9899-0812
Denis J WakehamInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0002-4200-3790
Tiffany L BrazileInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0001-8215-2144
Abidan AbulimitiInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0001-8504-0981
Kevin C LutzO'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Benjamin D LevineInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0001-9064-7251
Satyam SarmaInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Tony G BabbInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Bryce N BalmainInstitue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.ORCID 0000-0002-2642-7083

Funding

Targeting skeletal muscle to improve exercise capacity in heart failure with preserved ejection fraction.P01HL137630 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BABB, TONY G · 2019 to 2023
$11.4M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Training in Cardiovascular ResearchT32HL125247 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI JOSEPH A HILL · 2015 to 2026
$4.3M
HHS | National Institutes of Health (NIH) P01HL137630NHLBI NIH HHS P01 HL137630NHLBI NIH HHS T32 HL125247NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

Some patients with heart failure with preserved ejection fraction (HFpEF) have demonstrated evidence of exercise-induced arterial hypoxaemia (EIAH). However, EIAH was not quantified using

Indexed as

ExerciseHeart FailureHypoxiaStroke VolumeAgedFemaleHumansMaleMiddle AgedOxygen Consumptionexercise‐induced arterial hypoxaemiagas exchangeHFpEF

Identifiers

PMID40914966
PMCPMC12961696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.