Evidence map›Paper›PMID 40914919›Full record

ArticleMolecular diversity2026

9-fluorenone-based synthetic sulfonamide compounds as dual inhibitors of SARS-CoV-2 Main-Protease and Papain-like Protease.

Sudesna Das, Prasad Sunnapu, Mohammed Rafi, Yasmin Begum, Sudip Dey, Akshay Joshi, Nittu Singh, Krishan Gopal Thakur, Parasuraman Jaisankar, Umesh Prasad Singh

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sudesna DasAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Prasad SunnapuOrganic and Medicinal Chemistry Division, Laboratory of Catalysis and Chemical Biology, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India.
Mohammed RafiAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Yasmin BegumInfectious Diseases and Immunology Division, Council of Scientific and Industrial Research- Indian Institute of Chemical Biology (CSIR-IICB), Jadavpur, Kolkata, 700032, India.
Sudip DeyAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Akshay JoshiCouncil of Scientific and Industrial Research- Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India.
Nittu SinghCouncil of Scientific and Industrial Research- Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India.
Krishan Gopal ThakurCouncil of Scientific and Industrial Research- Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India.
Parasuraman JaisankarAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Umesh Prasad SinghAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. umesh.singh@iicb.res.in.ORCID http://orcid.org/0000-0003-2607-9485

Funding

Council of Scientific and Industrial Research, India HCP-41CSIR - Indian Institute of Chemical Biology OLP116CSIR - Indian Institute of Chemical Biology OLP118
6 · The paper itself

Abstract

Tilorone, a 9-fluorenone scaffold-based molecule, is a known broad-spectrum antiviral with an IC

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesFluorenesProtease InhibitorsSARS-CoV-2SulfonamidesCOVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationAntiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesFluorenespapain-like protease, SARS-CoV-2Protease InhibitorsSulfonamides9-fluorenone scaffoldBased dockingDual-protease inhibitorFRET-based assayHigh-throughput screeningIn-silico structureMain protease (Mpro)Molecular dynamics (MD) simulationPapain-like protease (PLpro)SARS-CoV-2Sulfonamide derivativesTilorone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.