ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025
Excess copper exposure and male reproductive toxicity: molecular mechanisms and potential interventions.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Copper (Cu) is an essential micronutrient in various enzymatic and physiological functions. However, excessive copper intake, mainly resulting from industrial emissions and improper agricultural practices, has raised growing concerns due to its toxicological effects, particularly on the male reproductive system. This review summarizes current research progress on copper-induced reproductive toxicity in males, emphasizing its impact on sperm quality, androgen production, and testicular structure and function. The underlying molecular mechanisms are discussed in detail, including oxidative stress, apoptosis, autophagy, ferroptosis, and cuproptosis. In addition, emerging therapeutic approaches, such as antioxidant treatments and copper chelators, are evaluated for their potential to mitigate these toxic effects. A comprehensive understanding of copper-induced male reproductive toxicity may offer new insights into the prevention and management of metal-related infertility.
Indexed as
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40914915What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.