Evidence map›Paper›PMID 40914805›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 m

Junjie Gou, Yi Wang, Jingjing Feng, Kaijing Chang, Kexin Wang, Jingjing Bi, Junqi Ge, Chongfu Zhao, Songdi Wu, Zengqi Tan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. O-GlcNAcylation locks the m6A-SRSF1-MCL1 axis in myeloid malignancies.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junjie GouXi'an No. 1 Hospital, First Affiliated Hospital of Northwest University, School of Medicine, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Yi WangDepartment of Hematology, Provincial People's Hospital, Xi'an, China.
Jingjing FengKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Kaijing ChangKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Kexin WangKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Jingjing BiKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Junqi GeKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Chongfu ZhaoKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Songdi WuXi'an No. 1 Hospital, First Affiliated Hospital of Northwest University, School of Medicine, Xi'an, China.
Zengqi TanKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China.
Feng GuanKey Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China. Electronic address: guanfeng@nwu.edu.cn.
Xiang LiXi'an No. 1 Hospital, First Affiliated Hospital of Northwest University, School of Medicine, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an, China; Institute of Hematology, School of Medicine, Northwest University, Xi'an, China. Electronic address: xiangli@nwu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N6-methyladenosine (m

Indexed as

AcetylglucosamineAdenosineLeukemia, Myeloid, AcuteMethyltransferasesMyelodysplastic SyndromesSerine-Arginine Splicing FactorsAnimalsApoptosisCell Line, TumorDisease ProgressionGlycosylationHumansMaleMiceProtein Processing, Post-TranslationalAcetylglucosamineAdenosineMethyltransferasesMETTL3 protein, humanN-methyladenosineSerine-Arginine Splicing FactorsAMLgene splicingIGF2BP2m(6)A modificationMCL-1MDSMETTL3O-GlcNAcSRSF1targeted therapy

Identifiers

PMID40914805
PMCPMC12703143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.