Evidence map›Paper›PMID 40914770›Full record

ArticleMikrochimica acta2025

Label-free immunoassay based on chemiluminescence-functionalized magnetic mesoporous nanoparticles for rapid detection of neuron-specific enolase.

Wenxia Chen, Shuangyi Hu, Bingqian Zhou, Yueran Ren, Yangyang Xue, Rui Yang

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Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenxia Chen *The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Binhu Hospital of Hefei, Hefei, 230061, P. R. China.
Shuangyi Hu *The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Binhu Hospital of Hefei, Hefei, 230061, P. R. China.
Bingqian ZhouThe Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Binhu Hospital of Hefei, Hefei, 230061, P. R. China.
Yueran RenThe Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Binhu Hospital of Hefei, Hefei, 230061, P. R. China.
Yangyang XueThe First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China.
Rui YangThe Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Binhu Hospital of Hefei, Hefei, 230061, P. R. China. yangrui@ahmu.edu.cn.

Funding

Discipline Construction Project of School of Pharmaceutical Sciences 2023xkjd12Natural Science Foundation of Anhui Province 2108085QH378Research Foundation of Anhui Medical University 0601090201State Key Laboratory of Analytical Chemistry for Life Science SKLACLS2301
6 · The paper itself

Abstract

Lung cancer, as one of the cancers with the highest morbidity and mortality rates in the world, requires accurate detection of its vital serum marker, neuron-specific enolase (NSE), which is a key challenge for early detection of lung cancer. However, traditional chemiluminescence immunoassay (CLIA) methods rely on labeled antibodies (Abs) and suffer from complex operations and high costs. In this work, a label-free CLIA based on CL-functionalized mesoporous magnetic nanoparticles (CuFe

Indexed as

Luminescent MeasurementsMagnetite NanoparticlesPhosphopyruvate HydrataseAntibodies, ImmobilizedCysteineGoldHumansImmunoassayLimit of DetectionLuminolMetal NanoparticlesPorositySilicon DioxideAntibodies, ImmobilizedCysteineGoldLuminolMagnetite NanoparticlesPhosphopyruvate HydrataseSilicon DioxideChemiluminescence immunoassayLabel-freeLung cancerMagnetic mesoporous nanoparticlesNeuron-specific enolase

Identifiers

PMID40914770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.