Evidence map›Paper›PMID 40914759›Full record

ArticleInternational journal of impotence research2026

Comparing sexual outcomes and complications in Male-to-Female Gender-Affirming Surgery: penile inversion vs. robotic peritoneal vaginoplasty.

Alessandro Zucchi, Giuseppe Maiolino, Marco Falcone, Alessandro Perotti, Eleonora Sollazzi, Giada Macrì, Juan Ignacio Martínez-Salamanca, Antonio Luigi Pastore, Riccardo Bartoletti, Matteo Pacini

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International journal of impotence research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro ZucchiUrology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Giuseppe MaiolinoLyx Institute of Urology, Universidad Francisco de Vitoria, 28223, Madrid, Spain. giu.maiolino@lyxurologia.com.ORCID http://orcid.org/0000-0002-3269-7434
Marco FalconeDepartment of Urology, Molinette Hospital, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.ORCID http://orcid.org/0000-0003-1101-892X
Alessandro PerottiUrology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Eleonora SollazziUrology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Giada MacrìUrology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Juan Ignacio Martínez-SalamancaLyx Institute of Urology, Universidad Francisco de Vitoria, 28223, Madrid, Spain.
Antonio Luigi PastoreDepartment of Medical and Surgical Science and Biotechnology, La Sapienza University, Rome, Italy.
Riccardo BartolettiUrology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.ORCID http://orcid.org/0000-0002-0021-0302
Matteo PaciniUrology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gender dysphoria is a condition characterized by distress due to a mismatch between a person's gender identity and their assigned gender at birth. This study aimed to compare sexual satisfaction and complication rates in patients undergoing feminizing gender affirming surgery (fem-GAS) using two techniques: standard penile inversion vaginoplasty (PIV) and robotic peritoneal vaginoplasty (RPGAV). We conducted a retrospective analysis data from a prospective registry (2017-2022). All patients had at least two years of hormone therapy. Sexual satisfaction was evaluated one year postoperatively using a custom Likert scale-based questionnaire developed in collaboration with our psychosexologist. We also performed a non-systematic review of the literature on sexual outcomes following LPGAV and RPGAV. We included 19 patients (PIV = 11; RPGAV = 8). Median age at surgery was 32 years. No significant differences were observed between groups regarding preoperative characteristics or complication rates. One Clavien-Dindo grade >3b complication occurred in RPGAV group. Compared to the PIV group, patients in the RPGAV group reported significantly (p = 0.04) higher improvement in "quality of sexual intercourse" (87.5 vs. 27.3%) and "overall sexual satisfaction" (87.5 vs. 27.3%). No significant differences were found in orgasm quality, speed, or erogenous sensitivity. Although literature data on sexual outcomes remain limited, RPGAV may provide better satisfaction, particularly regarding vaginal width, depth, and lubrication, with similar complication rates. Although our study is limited by its small sample size and retrospective design, it represents the first direct comparison between these techniques. Larger prospective studies are needed to confirm these findings.

Indexed as

Gender-Affirming SurgeryGender DysphoriaPenisPostoperative ComplicationsRobotic Surgical ProceduresVaginaAdultFemaleHumansMaleOrgasmRetrospective StudiesTreatment OutcomeYoung Adult

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.